Rat testis during 2,5-hexanedione intoxication and recovery: I. Dose response and the reversibility of germ cell loss☆
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Chronic oral toxicity of 3-nitro-1,2,4-triazol-5-one (NTO) in rats
2020, Regulatory Toxicology and PharmacologyCitation Excerpt :Because Sertoli cells are extremely resistant to cell death, prolonged dosing often results in seminiferous tubules lined only with Sertoli cells (Creasy, 1997). Although resistant to cell death, Sertoli cells are sensitive to alterations in function and are a target of testicular toxicants including 2,5-hexandione, tri-o-cresyl phosphate, 1,3-dinitrobenzene, cyclohexylamine, perfluorooctanesulfonic acid (PFOS), and phthalate esters (Blackburn et al., 1988; Boekelheide, 1988; Chapin et al., 1983; Creasy et al., 1987, 1990; Qiu et al., 2013; Somkuti et al., 1991). Time-course studies in rats and mice indicate that the Sertoli cell is also the initial target of testicular toxicity for NTO (Lent et al., 2018; Mullins et al., 2016).
The Sertoli Cell as a Target for Toxicants
2018, Comprehensive Toxicology: Third EditionIs toxicant-induced Sertoli cell injury in vitro a useful model to study molecular mechanisms in spermatogenesis?
2016, Seminars in Cell and Developmental BiologyHormonal regulation of c-KIT receptor and its ligand: Implications for human infertility?
2014, Progress in Histochemistry and CytochemistryCitation Excerpt :Some of the beneficial effects of GnRH administration are coupled to the regulation of SCF levels in testicular and ovarian cells. The exposure of rats to the hexane metabolite 2,5-hexanedione (2,5-HD) has shown to induce irreversible testicular atrophy (Boekelheide, 1988; Chapin et al., 1983). The testicular injury induced by 2,5-HD is accompanied by the reduced expression of SCF and an altered localization of protein, shifting from a predominant distribution at plasma membrane to a soluble form (Allard et al., 1996).
The Sertoli Cell as a Target for Toxicants
2010, Comprehensive Toxicology, Second Edition
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This work was supported by Grant R01 OH02191 from the National Institute for Occupational Safety and Health of the Centers for Disease Control and a Pharmaceutical Manufacturers Association Foundation Faculty Development Award in Toxicologic Pathology.