Abstract
Objectives
We evaluated cancer risk from DDVP (2,2-Dichloroethenyl dimethylphosphate) exposure among pesticide applicators enrolled in the Agricultural Health Study (AHS) cohort.
Methods
The AHS is a cohort of 57,311 pesticide applicators in North Carolina and Iowa, enrolled from 1993 to 1997 and followed for cancer through 2004. A comprehensive questionnaire collected information on exposure to DDVP and potential confounders. Among the 49,762 licensed pesticide applicators eligible for analysis, 4,613 reported use of DDVP. DDVP exposure was classified as intensity-weighted cumulative exposure days (IWED), calculated as [years of use × days per year × intensity level]. Poisson regression analysis was used to calculate rate ratios (RR) and 95% confidence intervals (CI) to evaluate the association of DDVP exposure among 2,943 incident cases of cancer.
Results
DDVP exposure was not associated with any cancer studied here. We observed no elevation in risk among lymphohematopoietic cancers, RR = 1.00 (95% CI 0.51, 1.96) and a small excess risk associated with exposure among those with a family history of prostate cancer (RR = 1.18 (95% CI 0.73, 1.82).
Conclusion
We find little evidence of an association between cumulative lifetime use of DDVP and risk of any cancer at this stage of follow up of the AHS.
Similar content being viewed by others
Abbreviations
- (DDVP):
-
Dichlorvos
- (AHS):
-
Agricultural Health Study
- (IWED):
-
Intensity-weighted cumulative exposure days
- (EPA):
-
Environmental Protection Agency
- (IARC):
-
International Agency for Cancer Research
- (OR):
-
Odds ratio
- (CI):
-
Confidence interval
- (RR):
-
Rate ratio
References
Wayland Hayes J (1982) Pesticides studied in man. Williams and Wilkins, Baltimore
Agency for Toxic Substances and Disease Registry (ATSDR) (1997) Toxicological profile for dichlorvos. Atlanta, GA
Davis JR, Brownson RC, Garcia R (1992) Family pesticide use in the home, garden, orchard, and yard. Arch Environ Contam Toxicol 22:260–266
U.S.EPA (U.S. Environmental Protection Agency) (1995) Dichlorvos (DDVP); Deletion of certain uses and directions
IARC(1991) Occupational exposures in insecticide application, and some pesticides. IARC working group on the evaluation of carcinogenic risks to humans. Lyon, 16–23 October 1990. IARC Monogr Eval Carcinog Risks Hum 53:5–586
NTP (1989) Toxicology and Carcinogenesis Studies of Dichlorvos (CAS NO. 62–73–7) In F344/N rates and B6C3Fi Mice (Gavage Studies). Technical Report Series No. 342. U.S. Department of Health and Human Services Public Health Service National Institutes of Health
U.S.EPA (U.S. Environmental Protection Agency) (2002) Integrated risk information system database for risk assessment: Dichlorvos
Ishmael J, Macgregor JA, Manley A (2006) Dichlorvos-a comprehensive review of 11 rodent carcinogenicity studies. Regul Toxicol Pharmacol 44(3):238–248
Li Q, Nakadai A, Takeda K, Kawada T (2004) Dimethyl 2,2-dichlorovinyl phosphate (DDVP) markedly inhibits activities of natural killer cells, cytotoxic T lymphocytes and lymphokine-activated killer cells via the Fas-ligand/Fas pathway in perforin-knockout (PKO) mice. Toxicology 204:41–50
Cankayali I, Demirag K, Eris O, Ersoz B, Moral AR (2005) The effects of N-acetylcysteine on oxidative stress in organophosphate poisoning model. Adv Ther 22:107–116
Yamano T (1996) Dissociation of DDVP-induced DNA strand breaks from oxidative damage in isolated rat hepatocytes. Toxicology 108:49–56
Cantor KP, Blair A, Everett G et al (1992) Pesticides and other agricultural risk factors for non-Hodgkin’s lymphoma among men in Iowa and Minnesota. Cancer Res 52:2447–2455
De Roos AJ, Zahm SH, Cantor KP et al (2003) Integrative assessment of multiple pesticides as risk factors for non-Hodgkin’s lymphoma among men. Occup Environ Med 60:E11
Reeves JD, Driggers DA, Kiley VA (1981) Household insecticide associated aplastic anaemia and acute leukaemia in children. Lancet 2: 300–301
Brown LM, Blair A, Gibson R et al (1990) Pesticide exposures and other agricultural risk factors for leukemia among men in Iowa and Minnesota. Cancer Res 50:6585–6591
Flower KB, Hoppin JA, Lynch CF et al (2004) Cancer risk and parental pesticide application in children of Agricultural Health Study participants. Environ Health Perspect 112:631–635
Mills PK, Yang R (2003) Prostate cancer risk in California farm workers. J Occup Environ Med 45:249–258
Alavanja MC, Samanic C, Dosemeci M et al (2003) Use of agricultural pesticides and prostate cancer risk in the Agricultural Health Study cohort. Am J Epidemiol 157:800–814
Alavanja MC, Sandler DP, McMaster SB et al (1996) The Agricultural Health Study. Environ Health Perspect 104:362–369
Leighton TM (1995) The United Stated Environmental Protection Agency, Health Canada, and National Agricultural Chemicals Association Pesticide Handlers Exposure Database. Appl Occup Environ Hyg 10:270–273
Dosemeci M, Alavanja MC, Rowland AS et al (2002) A quantitative approach for estimating exposure to pesticides in the Agricultural Health Study. Ann Occup Hyg 46:245–260
Mahajan R, Blair A, Lynch CF et al (2006) Fonofos exposure and cancer incidence in the agricultural health study. Environ Health Perspect 114:1838–1842
Dunier M, Siwicki AK, Demael A (1991) Effects of organophosphorus insecticides: effects of trichlorfon and dichlorvos on the immune response of carp (Cyprinus carpio). III. In vitro effects on lymphocyte proliferation and phagocytosis and in vivo effects on humoral response. Ecotoxicol Environ Saf 22:79–87
Zabrodskii PF, Germanchuk VG, Kirichuk VF, Birbin VS, Chuev AN (2002) Combined effects of toxicants with various mechanisms of action and mechanical trauma on the immune system. Bull Exp Biol Med 133:594–596
Blair A, Tarone R, Sandler D et al (2002) Reliability of reporting on life-style and agricultural factors by a sample of participants in the Agricultural Health Study from Iowa. Epidemiology 13:94–99
Hoppin JA, Yucel F, Dosemeci M, Sandler DP (2002) Accuracy of self-reported pesticide use duration information from licensed pesticide applicators in the Agricultural Health Study. J Expo Anal Environ Epidemiol 12:313–318
Acknowledgments
This research was supported by the Intramural Research Program of the National Institutes of Health (National Cancer Institute (Division of Cancer Epidemiology and Genetics) and National Institute of Environmental Health Sciences) and by grant TU2 CA105666 from the National Cancer Institute. We thank the participants in the Agricultural Health Study for their contributions in support of this research.
Author information
Authors and Affiliations
Corresponding author
Rights and permissions
About this article
Cite this article
Koutros, S., Mahajan, R., Zheng, T. et al. Dichlorvos exposure and human cancer risk: results from the Agricultural Health Study. Cancer Causes Control 19, 59–65 (2008). https://doi.org/10.1007/s10552-007-9070-0
Received:
Accepted:
Published:
Issue Date:
DOI: https://doi.org/10.1007/s10552-007-9070-0