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Inhibition of function of T cell subpopulations and decrease in cytokine production during subacute poisoning with various toxicants

  • Biophysics and Biochemistry
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Bulletin of Experimental Biology and Medicine Aims and scope

Experiments on outbred albino rats showed that subacute intoxication with organophosphorus compounds dimethyldichlorovinyl phosphate and malathion primarily decreased functional activity of Th1 lymphocytes, immune reactions associated with these cells, and interferon-γ production compared to that of Th2 lymphocytes and interleukin-4 synthesis. Acrylic acid nitrile and methanol produced the opposite effect. Sulfur mustard and sodium arsenite were equally potent in reducing the function of Th1 and Th2 lymphocytes and production of cytokines.

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Authors and Affiliations

  1. Saratov Military Institute of Radiational, Chemical, and Biological Protection, Saratov, Russia

    P. F. Zabrodskii, V. G. Germanchuk & V. G. Mandych

Authors
  1. P. F. Zabrodskii
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  2. V. G. Germanchuk
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  3. V. G. Mandych
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Correspondence to P. F. Zabrodskii.

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Translated from Byulleten' Eksperimental'noi Biologii i Meditsiny, Vol. 146, No. 8, pp. 200–203, August, 2008

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Zabrodskii, P.F., Germanchuk, V.G. & Mandych, V.G. Inhibition of function of T cell subpopulations and decrease in cytokine production during subacute poisoning with various toxicants. Bull Exp Biol Med 146, 234–236 (2008). https://doi.org/10.1007/s10517-008-0256-6

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  • DOI: https://doi.org/10.1007/s10517-008-0256-6

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