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Evaluation of dermal absorption and protective effectiveness of respirators for xylene in spray painters

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Abstract

Objectives

To determine the contribution of dermal absorption on the total exposure dose and the performance of respirators in the field for xylene in spray painters.

Methods

Eighteen male spray painters worked at shipyard were recruited for this study. The subjects were monitored during a 3-day-work period using a repeated-measures study design. Personal exposure to xylene outside and inside mask were collected using two 3 M model 3500 organic vapor monitors, respectively. Urine was collected before and after the work shift and urinary methyl hippuric acid (MHA) was determined. Total 98 of air and urine samples were obtained, respectively.

Results

Air sampling results showed that workers were primarily exposed to xylene and ethyl benzene. Xylene and ethyl benzene concentrations outside the mask were 52.6 ± 63.7 (mean ± SD) and 33.2 ± 32.4 ppm, and concentrations inside the mask were 2.09 ± 2.74 and 1.79 ± 2.16 ppm, respectively. The median workplace protection factors of respirators for xylene and ethyl benzene were 25.0 and 17.4, respectively. On average, workers could reduce xylene inhalation by 96% and ethyl benzene inhalation by 94% for wearing respirators. A significant correlation (R 2 = 0.935; P < 0.001) was found between the WPFs for xylene and ethyl benzene. Total urinary MHA concentration was 240.2 ± 42.3 (mean ± SE) mg/g creatinine, whereas urinary MHA via skin absorption was estimated to be 202.1 ± 40.1 mg/g creatinine. The contribution of dermal absorption to the total exposure dose of xylene was 64 ± 4.3%.

Conclusion

The present study showed that inhalation of solvent vapors in workers decreased as a result of wearing respirators and dermal exposure became the main contributor to the total body burden of solvents. Because workers had different attitude and behavior to wear respirators, the measured workplace protection factors varied. It is therefore equally important to prevent from being exposed to solvents through skin for shipyard spray painters.

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References

  • Aitio A, Pekari K, Jarvisalo J (1984) Skin absorption as a source of error in biological monitoring. Scand J work Environ Health 10:317–320

    PubMed  CAS  Google Scholar 

  • American Conference of Governmental Industrial Hygienists (ACGIH) (1996) Threshold limit values for chemical substances and physical agents and biological exposure indices, Cincinnati, OH

  • Baker EL, Smith TJ, Landrigan PJ (1985) The neurotoxicity of industrial solvents. Am J Ind Med 8:207–217

    Article  PubMed  CAS  Google Scholar 

  • Berger-Preiß E, Boehncke A, Könnecker G, Mangelsdorf I, Holthenrich D, Koch W (2005) Inhalational and dermal exposures during spray application of biocides. Int J Hyg Environ Health 208:357–372

    Article  PubMed  Google Scholar 

  • Brooke I, Cocker J, Delic JI, Payne M, Jones K, Gregg NC, Dyne D (1998) Dermal uptake of solvents from the vapour phase: an experimental study in humans. Ann Occup Hyg 42:531–540

    PubMed  CAS  Google Scholar 

  • Cohen HJ (1984) Determining and validating the adequacy of air-purifying respirators used in industry. Part I. Evaluating the performance of a disposable respirator for protection against mercury vapor. J Int Soc Respir Prot 2:296–304

    Google Scholar 

  • Daniell W, Stebbins A, Kalman D, O’Donnell JF, Horstman SW (1992) The contributions to solvent uptake by skin and inhalation exposure. Am Ind Hyg Assoc J 53:124–129

    PubMed  CAS  Google Scholar 

  • Engstrom K, Husman K, Pfaffli P, Riihimaki V (1978) Evaluation of occupational exposure to xylene by blood, exhaled air and urine analysis. Scand J Work Environ Health 4:114–121

    PubMed  CAS  Google Scholar 

  • Engstrom K, Riihimaki V, Laine A (1984) Urinary disposition of ethylbenzene and m-xylene in man following separate and combined exposure. Int Arch Environ Health 54:355–363

    Article  CAS  Google Scholar 

  • Galvin K, Selvin S, Spear RC (1990) Variability in protection afforded by half mask respirators against styrene exposure in the field. Am Ind Hyg Assoc J 51:625–631

    PubMed  CAS  Google Scholar 

  • Jacobson GA, McLean S (2003) Biological monitoring of low level occupational xylene exposure and the role of recent exposure. Ann occup Hyg 47(4):331–336

    Article  PubMed  CAS  Google Scholar 

  • Jang JY, Droz PO, Kim S (2001) Biological monitoring of workers exposed to ethylbenzene and co-exposed to xylene. Int Arch Occup Environ Health 74:31–37

    Article  PubMed  CAS  Google Scholar 

  • Larsen RS (1986) A practical field method for measuring the effectiveness of intermittent respirator usage. Am Ind Hyg Assoc J 47(12):A775–776

    PubMed  CAS  Google Scholar 

  • Lees PSJ, Corn M, Breysse PN (1987) Evidence for dermal absorption as the major route of body entry during exposure of transformer maintenance and repairmen to PCBs. Am Ind Hyg Assoc J 48:257–264

    PubMed  CAS  Google Scholar 

  • Loizou GD, Jones K, Akrill P, Dyne D, Cocker J (1999) Estimation of the dermal absorption of m-xylene vapor in humans using breath sampling and physiologically based pharmacokinetic analysis. Toxicol Sci 48:170–179

    Article  PubMed  CAS  Google Scholar 

  • Lundberg I, Sollenberg J (1986) Correlation of xylene exposure and methyl hippuric acid excretion in urine among paint industry workers. Scand J Work Environ Health 12:149–153

    PubMed  CAS  Google Scholar 

  • Mao IF, Chen ML, Lo EW (1996) Simultaneous determination of urinary metabolites of toluene, xylene, styrene and ethyl benzene by solid-phase extraction technique and high-performance liquid chromatographic/photo diode array detection. Int J Environ Anal Chem 64:1–9

    CAS  Google Scholar 

  • Savolainen K, Riihimaki V (1984) Immediate effects of m-xylene on the human central nervous system. Arch Toxicol 84:412–417

    Google Scholar 

  • Tassanuyakul W, Birkett DJ, Edwards JW, Veronese ME, Tassaneeyakul W, Tukey RH, Miners JO (1996) Human cytochrome P450 isoform specificity in the regioselective metabolism of toluene and o-, m-, and p-xylene. J Pharm Exp Ther 276(1):101–108

    Google Scholar 

  • Taussky HH (1954) A micro-colorimetric determination of creatine in urine by the Jaffe reaction. J Biol Chem 208:853–861

    PubMed  CAS  Google Scholar 

  • Toftgard R, Nilsen OG (1982) Effect of xylene and xylene isomers on cytochrome P-450 and in vitro enzymatic activities in rat liver, kindney and lung. Arch Toxicol 23:197–212

    CAS  Google Scholar 

  • Zhuang Z, Myers WR (1998) Field performance measurements of half- facepiece respirators–correlation between workplace protection factors and fit factors. Paper presented at the American industrial hygiene conference and exposition, Atlanta, GA, May 9–15

  • Zhuang Z, Coffey CC, Jensen PA, Campbell DL, Lawrence RB, Myers WR (2003) Correlation between quantitative fit factors and workplace protection factors measured in actual workplace environments at a steel foundry. Am Ind Hyg Assoc J 64:730–738

    CAS  Google Scholar 

  • 3M, Occupational Health and Environmental Safety Division (1996a) Technical data bulletins, issue no. 1119. 3M™ Organic vapor monitors—toluene. Available at: http://solutions.3m.com/wps/portal/3M/en_US/Occupational-Health/Environmental-Safety/Literature-Publications/Technical-Data-Bulletins/

  • 3M, Occupational Health and Environmental Safety Division (1996b) Technical data bulletins, issue no. 125. 3M™ diffusion monitors—storage and recovery. Available at: http://solutions.3m.com/wps/portal/3M/en_US/Occupational-Health/ Environmental-Safety/Literature-Publications/Technical-Data-Bulletins/

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Acknowledgments

The authors would thank the Council of Labor Affairs of the Republic of China, Taiwan, for financially supporting this research under Contract No. IOSH94-A309. The spray painters who participated in this study are also appreciated.

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Correspondence to I-Fang Mao.

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Chang, FK., Chen, ML., Cheng, SF. et al. Evaluation of dermal absorption and protective effectiveness of respirators for xylene in spray painters. Int Arch Occup Environ Health 81, 145–150 (2007). https://doi.org/10.1007/s00420-007-0197-9

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  • DOI: https://doi.org/10.1007/s00420-007-0197-9

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