Abstract
Incidence and mortality from cerebrovascular diseases (CVD) (430–438 ICD-9 codes) have been studied in a cohort of 18,763 workers first employed at the Mayak Production Association (Mayak PA) in 1948–1972 and followed up to the end of 2005. Some of the workers were exposed to external gamma-rays only while others were exposed to a mixture of external gamma-rays and internal alpha-particle radiation due to incorporated 239Pu. After adjusting for non-radiation factors, there were significantly increasing trends in CVD incidence with total absorbed dose from external gamma-rays and total absorbed dose to liver from internal alpha radiation. The CVD incidence was statistically significantly higher among workers with total absorbed external gamma-ray doses greater than 0.20 Gy compared to those exposed to lower doses; the data were consistent with a linear trend in risk with external dose. The CVD incidence was statistically significantly higher among workers with total absorbed internal alpha-radiation doses to liver from incorporated 239Pu greater than 0.025 Gy compared to those exposed to lower doses. There was no statistically significant trend in CVD mortality risk with either external gamma-ray dose or internal alpha-radiation dose to liver. The risk estimates obtained are generally compatible with those from other large occupational studies, although the incidence data point to higher risk estimates compared to those from the Japanese A-bomb survivors. Further studies of the unique cohort of Mayak workers chronically exposed to external and internal radiation will allow improving the reliability and validating the radiation safety standards for occupational and public exposure.
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Notes
The category of ‘plutonium production plant’ includes workers, who have ever worked at the plutonium production plant; the category of ‘radiochemical plant’ includes those, who have worked at the radiochemical plant, but never at the plutonium production plant; the category of ‘reactors’ includes workers, who have worked at the reactors, but never at the other two plants.
The ‘never smokers’ are workers, who have claimed to be never smokers at several medical examinations.
The ‘never drinkers’ are workers, who have claimed to be never drinkers at several medical examinations.
The ‘hypertension’ is a condition in which the arterial blood pressure is over 140/90 mm hg.
The ‘normal body mass index’ is equal to 18.5–24.99 kg/m2.
References
Azizova TV, Day RD, Wald N, Muirhead CR, O’Hagan JA, Sumina MV, Belyaeva ZD, Druzhinina MB, Teplyakov II, Semenikhina NG, Stetsenko LA, Grigoryeva ES, Krupenina LN, Vlasenko EV (2008) The “Clinic” medical-dosimetric database of Mayak production association workers: structure, characteristics and prospects of utilization. Health Phys 94:449–458
Azizova TV, Muirhead CR, Druzhinina MB, Grigoryeva ES, Vlasenko EV, Sumina MV, O’Hagan JA, Zhang W, Haylock RGE, Hunter N (2010) Cerebrovascular diseases in the cohort of workers first employed at Mayak PA in 1948–1958. Radiat Res 174:851–864
Azizova TV, Muirhead CR, Moseeva MB, Grigoryeva ES, Vlasenko EV, Hunter N, Haylock RGE, O’Hagan JA (2011) Ischemic heart disease in the cohort of workers first employed at Mayak PA in 1948–1972. Health Phys (in press)
Donahue RP, Abbott RD, Reed DM, Yano K (1986) Alcohol and hemorrhage stroke. J Am Med Assoc 255:2311–2314
Fountos BN, Rabovsky JL (2007) The department of energy’s Russian health studies program. Health Phys 93(3):187–189
Guide to international statistical classification of diseases, traumas and causes of death (1980) Revision of 1975. Geneva: WHO
Hillbom M, Kaste M (1983) Ethanol intoxication: a risk factor for ischemic brain infarction. Stroke 14:694–699
Ivanov VK, Gorsky AI, Maksioutov MA, Tsyb AF, Souchkevitch GN (2001) Mortality among the Chernobyl emergency workers: estimation radiation risks. Health Phys 81(5):514–521
Ivanov V, Maksioutov MA, Chekin SY, Petrov AV, Biryukov AP, Kruglova ZG, Matyash VA, Tsyb AF, Manton KG, Kravchenko JS (2006) The risk of radiation-induced cerebrovascular disease in Chernobyl emergency workers. Health Phys 90:199–207
Kanareikin KF, Bakhur VT, Manvelov LS (1987) Alcohol and smoking as a risk factors for cerebral stroke. Clin Med 1:17–23 [in Russian]
Koshurnikova NA, Shilnikova NS, Okatenko PV (1999) Characteristics of the cohort of workers at the Mayak nuclear complex. Radiat Res 152(4):352–363
Kreuzer M, Kreisheimer M, Kandel M, Schnelzer M, Tschense A, Grosche B (2006) Mortality from cardiovascular diseases in the German uranium miners cohort study, 1946–1998. Radiat Environ Biophys 45:159–166
McGeoghegan D, Binks K, Gillies M, Jones S, Whaley S (2008) The non-cancer mortality experience of male workers at British Nuclear Fuels plc, 1946–2005. Int J Epidemiol 37:506–518
Muirhead CR, O’Hagan JA, Haylock RGE, Phillipson MA, Willcock T, Berridge GLC, Zhang W (2009) Mortality and cancer incidence following occupational radiation exposure: third analysis of the National Registry for Radiation Workers. Br J Cancer 100:206–212
Preston D, Lubin J, Pierce D, McConney M (1993) Epicure users guide. Hirosoft, Seattle, WA
Preston DL, Shimizu Y, Pierce DA, Suyama A, Mabuchi K (2003) Studies of mortality of atomic bomb survivors. Report 13: solid cancer and noncancer disease mortality: 1950–1997. Radiat Res 160:381–407
Shimizu Y, Kodama K, Nishi N, Kasagi F, Suyama A, Soda M, Grant EJ, Sugiyama H, Sakata R, Moriwaki H, Hayashi M, Konda M, Shore RE (2010) Radiation exposure and circulatory disease risk: Hiroshima and Nagasaki atomic bomb survivor data, 1950–2003. BMJ 340:b5349. doi:10.1136/bmj.b5349
Telnov VI (1985) Lipid metabolism in radiochemical plant workers exposed to ionizing radiation in doses below maximum permissible value. Radiat Med Bull 1:81–86 [in Russian]
Vasilenko EK, Khokhryakov VF, Miller SC, Fix JJ, Eckerman K, Choe DO, Gorelov M, Khokhryakov VV, Knyazev V, Krahenbuhl MP, Scherpelz RI, Smetanin M, Suslova K, Vostrotin V (2007a) Mayak worker dosimetry study: an overview. Health Phys 93(3):190–206
Vasilenko E, Gorelov M, Smetanin M, Knyazev V, Teplyakov I, Khokhriakov V, Khokhriakov V (Jr), Koshurnikova N, Shilnikova N, Okatenko P, Kreslov V, Bolotnikova M, Sokolnikov M, Suslova K, Romanov S, Alexandrova O, Miller S, Krahenbuhl M, Choe D, Anspaugh L, Eckerman K, Fix J, Scherpelz R, Napier B, Gilbert E (2007b) Mayak worker dosimetry study project 2.4, vol I: overview of dose assignment methodology for Mayak workers. Health Phys 93(3):7.13–7.19, CD-ROM
Vrijheid M, Cardis E, Ashmore P, Auvinen A, Bae JM, Engels H, Gilbert E, Gulis G, Habib R, Howe G, Kurtinaitis J, Malker H, Muirhead CR, Richardson DB, Rodriguez-Artalejo F, Rogel A, Schubauer-Berigan M, Tardy H, Telle-Lamberton M, Usel M, Veress K (2007) Mortality from diseases other than cancer following low doses of ionizing radiation: results from the 15-country study of nuclear industry workers. Int J Epidemiol 36:1126–1135
Yamada M, Wong FL, Fujiwara S, Akahoshi M, Suzuki G (2004) Non-cancer disease incidence in atomic bomb survivors, 1958–1998. Radiat Res 161:622–632
Acknowledgments
This study was conducted with support from the Federal Medical Biological Agency (FMBA Russia) and the European Commission (EC)’s Euratom Nuclear Fission and Radiation Protection Programme, through contract FP6-516478 “Southern Urals Radiation Risk Research” (SOUL), State Contract No. 11.309.06.0 “Clinical Epidemiological Assessment of Radiation Risks of Somatic (Non-Cancer) and Genetic Effects of Chronic Exposure”, and State Contract No. 11.311.09.0 “Effects of Chronic Exposure in the Mayak Workers Cohort”. The authors also would like to express their thanks and acknowledgements to the Mayak PA Radiation Safety Department headed by Mr. E.K. Vasilenko and to the SUBI Internal Dosimetry Department headed by Dr. V.V. Khokhryakov for access to the Mayak Doses-2005 database established in the framework of the Russian-American cooperation, to the SUBI Laboratory of Epidemiology headed by Dr. M.E. Sokolnikov and personally to Dr. N.A. Koshurnikova for access to the Medical Dosimetry Registry for Mayak PA workers, and to the SUBI Occupational Health Laboratory headed by Dr. F.D. Tretyakov for access to the Cause of Death Registry for Ozyorsk residents.
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Azizova, T.V., Muirhead, C.R., Moseeva, M.B. et al. Cerebrovascular diseases in nuclear workers first employed at the Mayak PA in 1948–1972. Radiat Environ Biophys 50, 539–552 (2011). https://doi.org/10.1007/s00411-011-0377-6
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DOI: https://doi.org/10.1007/s00411-011-0377-6