Abstract
Utilizing cause-of-death information and responses to questionnaires addressed to survivors, mortalities and health impairments in a cohort of workers occupationally exposed to pesticides were compared to occurrences in workers not pesticide exposed, over the period 1971–1977. Seventy-two percent of 2,620 pesticide-exposed workers, and 75 percent of 1,049 “controls”, recruited in 1971–73, were accounted for either by returned questionnaire or mortality. Disease incidence rates were studied in relation to broadly defined occupational subclasses, and to serum concentrations of organochlorine pesticides (OC1) measured at the time of recruitment.
Death by accidental trauma was unusually frequent among pesticide applicators. Mortalities from cancer and arteriosclerosis were not detectably different from those observed in the controls. Among survivors, dermatitis and skin cancer were unusually common in structural pest-control operators. Internal cancer was no more frequent in the intensively pesticide-exposed workers than in the controls, but it appeared to occur at an unusually high rate in workers characterized as “possibly pesticide-exposed”.
There were apparent associations between high serum pesticide OCl levels measured in 1971–73 and the subsequent appearance of hypertension, arteriosclerotic cardiovascular disease, and possibly diabetes. This could imply a causal role of any of the pesticidal and other environmental stresses to which these workers were exposed.
The limitations of this type of followup study are discussed.
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References
Casarett, L. J., G. C. Fryer, W. L. Yauger, Jr., and H. W. Klemmer: Organochlorine pesticide residues in human tissue—Hawaii. Arch. Environ. Health.17, 306 (1968).
Davies, J. E., W. F. Edmundson, A. Raffonelli, J. C. Cassady, and C. Morgade: The role of social class in human pesticide pollution. Am. J. Epidem.96, 334 (1972).
Deichmann, W. B.: Toxicology of DDT and related chlorinated hydrocarbon pesticides. J. Occup. Med.14, 285 (1972).
Keil, J. E., J. F. Finklea, S. H. Sandifer, and M. C. Miller: Pesticide exposure index (PEI). In G. Mamantov and W. D. Shults (ed.): Determination of Air Quality, p. 57. New York: Plenum (1972).
McMichael, A. J.: Standardized mortality ratios and the “healthy worker effect”: Searching beneath the surface. J. Occup. Med.18, 165 (1976).
Morgan, D. P., and L. I. Lin: Blood organochlorine pesticide concentrations, clinical hematology and biochemistry in workers occupationally exposed to pesticides. Arch. Environ. Contam. Toxicol.7, 423 (1978).
Pell, S., and C. A. D'Alonzo: Chronic disease morbidity and income level in an employed population. Am. J. Pub. Hlth.60, 116 (1970).
Radomski, J. L., W. B. Deichmann, and E. E. Clizer: Pesticide concentrations in the liver, brain, and adipose tissue of terminal hospital patients. Fd. Cosmet. Toxicol.6, 209 (1968).
Sandifer, S. H., J. E. Keil, J. F. Finklea, and R. H. Gadsden: Pesticide effects on occupationally exposed workers: A summary of four years observation of industry and farm volunteers in South Carolina. Ind. Med.41, 9 (1972).
Simmons, S. W.: Living labs that study how pesticides affect man. FDA Papers. Vol. 3, 13, Food and Drug Administration, 5600 Fishers Lane, Rockville, MD 20852 (1969).
U.S. Department of Commerce, Bureau of the Census, Washington, DC: Current population reports. Population estimates and projections series P-25, No. 721: Estimates of the population of the United States by age, sex, and race: 1970–1977, p. 20 (1978).
U.S. Department of Health, Education, and Welfare, Public Health Service, Health Resources Administration, National Center for Health Statistics, Washington, DC: Vital statistics of the United States, Volume 2, Part A-Mortality (1974).
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Morgan, D.P., Lin, L.I. & Saikaly, H.H. Morbidity and mortality in workers occupationally exposed to pesticides. Arch. Environ. Contam. Toxicol. 9, 349–382 (1980). https://doi.org/10.1007/BF01057414
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DOI: https://doi.org/10.1007/BF01057414