Summary
Immunological parameters were studied in a group of 24 cotton textile workers. These were volunteers from a cohort of 106 (83 women and 23 men) previously studied textile workers. A group of 30 employees from a bottle packing plant served as a control for the immunologic studies. The subgroup of volunteers undergoing immunologic testing did not differ from the original cohort of textile workers in age, sex, smoking history, or prevalence of most chronic respiratory symptoms, nor were there any significant differences in baseline lung function or across-shift changes. The 24 cotton worker volunteers underwent skin testing with extracts of cotton dust and cotton seed. Eight of these 24 (33.3%) had positive tests, and 5 of the 8 had elevated serum immunoglobulin E (IgE) levels. Only one of the 8 skin-test-positive workers had symptoms of byssinosis. Only 1 of 30 control workers' skin tested with cotton extract reacted, and none had an increased serum IgE level (P < 0.01). Both baseline lung function and across-shift changes did not differ between workers with positive and negative skin test reactions or between workers with normal and elevated IgE levels. Additionally, we studied the response in vitro of nonsensitized guinea pig trachea to cotton bract extract and demonstrated a dose-dependent contractile response. These data suggest that while immunological findings are frequent in textile workers, they correlate poorly with respiratory symptoms and function and may not be the basis for the airway obstruction seen in this disease.
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References
Ainsworth SK, Neuman REG (1981) Chemotaxins in cotton mill dust: possible etiologic agent(s) in byssinosis. Am Rev Resp Dis 124:280–284
Beck GJ, Schachter EN, Maunder LR, Schilling RSF (1982) A prospective study of chronic lung disease in cotton textile workers. Ann Intern Med 97:645–649
Bouhuys A (1976) Byssinosis: scheduled asthma in the textile industry. Lung 154:3–7
Buck MG, Schachter EN, Wall JH (1983) Cotton bract airway constriction agent: its chemical characteristics and its effects on human airways. In: Wakelyn PJ, Jacobs RR (eds) Proceedings of the seventh beltwide cotton dust research conference. National Cotton Council, San Antonio, pp 22–25
Buck MG, Wall JH, Schachter EN (1985) Cotton bract lung constricting agent(s). Cotton Dust Research Conference, New Orleans, pp 110–112
Buck MG, Schachter EN, Fick RB, Merrill WW, Cooper JAD Jr, Keirns JJ, Oliver J, Wall JH (1986) Biologic activity of purified cotton bract extract in man and guinea pig. Environ Health Perspect 66:37–44
Butcher BT, O'Neil CE, Jones RN (1983) The respiratory effects of cotton dust. In: Salvagio JE, Stankus RP (eds) Clinics in chest medicine, vol 4. WB Saunders, Philadelphia, pp 63–70
Cayton HR, Furness G, Maitland HB (1952) Studies on cotton dust in relation to byssinosis. Part II. Skin tests for allergy with extracts of cotton dust. Br J Ind Med 9:186–196
Cherniack RM, Raber MB (1972) Normal standards for ventilatory function using an automated wedge spirometer. Am Rev Respir Dis 106:38–46
Christiani DC, Eisen EA, Wegman DH, Ye TT, Gong ZC, La PI, Dai HL (1986a) Respiratory disease in cotton textile workers in the People's Republic of China. I. Respiratory symptoms. Scand J Work Environ Health 12:40–45
Christiani DC, Eisen EA, Wegman DH, Ye TT, Gong ZC, La PI, Dai HL (1986b) Respiratory disease in cotton textile workers in the People's Republic of China. II. Pulmonary function results. Scand J Work Environ Health 12:46–50
Commission de Communautes Européennes CECA (1971) Aide memoire pour la pratique de l'examen de la function ventilatoire par la spirographie. (Collection d'hygiene et de medicine du travail, no 11) Luxembourg
Davenport A, Patton WDM (1962) the pharmacological activity of extracts of cotton dust. Br J Ind Med 19:19–32
Edwards JH, Jones BM (1973) Pseudoimmune precipitation by the isolated byssinosis “antigen”. J Immunol 110:498–501
El Karim MAA, Osman Y, El Haimi YAA (1986) Byssinosis: environmental and respiratory symptoms among textile workers in Sudan. Int Arch Occup Environ Health 57:101–108
Ellisalde MH, Greenblatt GA (1979) The role of cyclic AMP and cyclic GMP in byssinosis. Am Ind Hyg Assoc J 40:1067–1074
Elwood JH, Elwood PJ, Campbell MJ, Stanford CF, Chivers A, Hey I, Brewster PC, Sweetnam PM (1986) Respiratory disability in ex-flax workers. Br J Ind Med 43:300–306
Fetisova AA, Titova SM, Aleksandrova OG, Alekseeva OG (1970) Allergenic properties of the cotton and flax-spinning mills dust. Gig Truda Prof Zabol 14:19–22
Hitchock M, Piscitelli DM, Bouhuys A (1973) Histamine release from human lung by a component of cotton bract and by compound 48/80. Arch Environ Health 26:177–182
Jones BT, Butcher BT, Hammad YY, Diem JE, Glindmeyer HW, Lehrer SB, Hughes JM, Weill H (1980) Interaction of atopy and exposure to cotton dust in the bronchoconstrictor response. Br J Ind Med 37:141–146
Kamat SR, Kamat GR, Salpekar VY, Lobo E (1981) Distinguishing byssinosis from chronic obstructive pulmonary disease. Am Rev Respir Dis 124:31–40
Kutz SA, Olenchock SA, Elliott JA, Pearson DJ, Major PC (1979) Antibody-independent complement activation by card-room cotton dust. Environ Res 19:405–414
Massoud A, Taylor G (1964) Byssinosis: antibody to cotton antigens in normal subjects and in cotton card-room workers. Lancet II:607–610
Medical Research Council Committee on the Aetiology of Chronic Bronchitis (1960) Standardized questionnaire on respiratory symptoms. Br Med J 2:1665
Merchant JA, Lumsden JC, Kilburn KH, O'Fallon WM, Ujda JR, Germino VH, Hamilton JD (1973) An industrial study of the biological effects of cotton dust and cigarette smoke exposure. JOM 15:212–221
Mundie TG, Pilia PA, Ainsworth SK (1985) Byssinosis: serum immunoglobulin and complement concentrations in cotton mill workers. Arch Environ Health 40:326–329
Oehling A, Gonzales de la Requera I, Vines Rueda JJ (1978) A contribution to the allergic ethyopathogenity of byssinosis. Respiration 29:155–160
O'Neil CE, Butcher BT, Salvagio JE (1982) Mechanisms in byssinosis: a review. In: Montalvo JG Jr (ed) Cotton dust: controlling an occupational health hazard. (ACS Symposium Series no 189) American Chemical Society, Washington, D.C., pp 145–162
O'Neil CE, Reed MA, Aukrust L, Butcher BT (1983) Studies on the antigenic composition of aqueous cotton dust extracts. Int Arch Allergy Appl Immunol 72:294–298
Petronio L, Bovenzi M (1983) Byssinosis and serum IgE concentrations in textile workers in an Italian cotton mill. Br J Ind Med 40:39–44
Popa V, Gavrilescu N, Preda N, Teculescu D, Plecias M, Cirstea M (1969) An investigation of allergy in byssinosis: sensitization to cotton, hemp, flax and jute antigens. Br J Ind Med 26:101–108
Russell JA, Gilberstadt ML, Rohrbach MS (1982) Constrictor effect of cotton bract extract on isolated canine trachealis strips. Am Rev Resp Dis 125:727–733
Rylander E, Haglind P (1986) Exposure of cotton workers in an experimental cardroom with reference to airborne endotoxins. Environ Health Perspect 66:83–86
Salvagio JE, O'Neil CE, Butcher BT (1986) Immunologic response to inhaled cotton dust. Environ Health Perspect 66:17–23
Schachter EN, Brown S, Zuskin E, Buck MG, Kolack B, Bouhuys A (1981) The effect of mediator-modifying drugs in cotton bract-induced bronchospasm. Chest 79:73S-77S
Schachter EN, Buck MG, Merrill WW, Askenase P, Witek TJ (1985) Skin testing with an aqueous extract of cotton bract. J Allergy Clin Immunol 76:481–487
Schilling RSF, Vigliani EC, Lammers B, Valic F, Gilson JC (1963) A report on a conference on byssinosis. Proceedings of the 14th international congress on occupational health, Madrid, pp 137–145
Sepulveda MJ, Castellan RM, Hankinson JL, Cocke JB (1984) Acute lung function response to cotton dust in atopic and nonatopic individuals. Br J Ind Med 41:487–491
Sheldon JM, Lowell RG, Mathews KP (1967) Manual of clinical allergy. WB Saunders, Philadelphia, pp 507–531
Witek TJ, Gundel RH, Wegner CD, Schachter EN, Buck MG (1988) Acute pulmonary response to cotton bract extract in monkeys: lung function and effects of mediators modifying compound. Lung 166:25–31
World Health Organization (1986) Early detection of occupational disease. WHO, Geneva, pp 235–238
Zuskin E, Valic F (1975) Change in the respiratory response to coarse cotton dust over a ten-year period. Am Rev Respir Dis 112:417–420
Zuskin E, Valic F, Bouhuys A (1976) Byssinosis and airway responsiveness due to exposure to textile dust. Lung 154:17–24
Zuskin E, Ivankovich D, Schachter EN, Witek TH (1991) A ten year follow-up study of cotton textile workers. Am Rev Respir Dis 143:301–305
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Supported in part by grant no. YF 733 from the National Institutes of Health, Bethesda, Maryland, USA, grant no. R01 OHO 2593-01A1 from the National Institute of Occupational Safety and Health, Centers for Disease Control, Atlanta, Georgia, USA, and the Henry and Catherine Gaissman Fund, New York, NY, USA
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Zuskin, E., Kanceljak, B., Schachter, E.N. et al. Immunological findings and respiratory function in cotton textile workers. Int. Arch Occup Environ Heath 64, 31–37 (1992). https://doi.org/10.1007/BF00625948
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DOI: https://doi.org/10.1007/BF00625948