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Occupational lead exposure and pituitary function

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Summary

Twenty-five moderately exposed lead workers (mean blood-lead level 1.9 γmol/l) had lower plasma levels of follicle stimulating hormone than 25 individually matched controls without occupational lead exposure (blood-lead level 0.2 μmol/l). In addition, the ten most heavily exposed individuals had higher levels of thyroid stimulating hormone, and the 14 workers under the age of 40 had decreased plasma levels of luteinizing hormone and serum levels of cortisol, as compared to the controls. All values were within “normal” reference limits. There was no significant change of the plasma testosterone level. These data indicate a complex effect on the endocrine system by moderate lead exposure, possibly mediated by changes at the hypothalamic-pituitary level. Besides the effect on hormone levels, there was also a decrease in plasma selenium level for the lead exposed workers.

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References

  • Assenato G, Paci C, Baser ME, Molinini R, Candela RG, Altamura BM, Giorgino R (1986) Sperm count suppression without endocrine dysfunction in lead-exposed men. Arch Environ Health 41:387–390

    Google Scholar 

  • Braunstein GD, Dahlgren J, Loriaux DL (1978) Hypogonadism in chronically lead-poisoned men. Infertility 1:33–51

    Google Scholar 

  • Calvin HI (1978) Selective incorporation of 75 Se into a polypeptide of the rat sperm tail. J Exp Zool 204:445–452

    Google Scholar 

  • Cullen MR, Kayne RD, Robins JM (1984) Endocrine and reproductive dysfunction in men associated with occupational inorganic lead intoxication. Arch Environ Health 39:431–440

    Google Scholar 

  • Erfurth EM, Hedner P (1987) Increased plasma gonadotropin levels in spontaneous hyperthyroidism reproduced by thyroxine but not by triiodothyronine administration to normal subjects. J Clin Endocrin Metab 64:698–703

    Google Scholar 

  • Ganther HE, Wagner PA, Sunde ML, Hoekstra WG (1973) Protective effects of selenium against heavy metal toxicities. In: Hemphill DD (ed) Trace substances in environmental health, vol 6, pp 247–252 University of Missouri Press, Colombia, M.O

    Google Scholar 

  • Gustafson Å, Schütz A, Andersson P, Skerfving S (1987) Small effect on plasma selenium by occupational lead exposure. Sci Tot Environ 66:39–43

    Google Scholar 

  • LaLonde L, Jean Y, Roberts KD, Chapdelaine A, Bleau G (1982) Fluorometry of selenium in serum or urine. Clin Chem 28:172–184

    Google Scholar 

  • Lancranjan I, Popescu HI, Gavanescu O, Klepsch I, Serbanescu M (1975) Reproductive ability of workmen occupationally exposed to lead. Arch Environ Health 30:396–401

    Google Scholar 

  • McConnell KP, Burton RM, Kute T, Higgins PJ (1979) Selenoproteins from rat testes cytosol. Biochim Biophys Acta 588:113–119

    Google Scholar 

  • Motsenbocker MA, Tappel AL (1982) A selenocysteine-containing selenium-transport protein in rat plasma. Biochem Biophys Acta 719:147–153

    Google Scholar 

  • Petrusz P, Weaver CM, Grant LD, Mushak P, Krigman MR (1979) Lead posioning and reproduction: effects on pituitary and serum gonadotropins in neonatal rats. Environ Res 19:383–391

    Google Scholar 

  • Robins JM, Cullen MR, Connors BB, Kayne RD (1983) Depressed thyroid indexes associated with occupational exposure to inorganic lead. Arch Intern Med 143:220–224

    Google Scholar 

  • Sandstead HH, Stant EG, Brill AB, Arias LI, Terry RT (1969) Lead intoxication and the thyroid. Arch Int Med 123:632–635

    Google Scholar 

  • Sandstead HH, Orth DN, Abe K, Stiel J (1970) Lead intoxication: effect on pituitary and adrenal function in man. Clin Res 18:76

    Google Scholar 

  • Silva JE, Larsen PR (1978) Contributions of plasma triiodothyronine and local thyroxine monodeiodination to triiodothyronine receptor saturation in pituitary liver and kidney of hypothyroid rats. J Clin Invest 61:1247

    Google Scholar 

  • Sokol RC (1987) Hormonal effects of lead acetate in the male rat: mechanism of action. Biol Reprod 37:1135–1138

    Google Scholar 

  • Svensson BG, Björnham Å, Schütz A, Lettevall U, Nilsson A, Skerfving S (1987) Acidic deposition and human exposure to toxic metals. Sci Tot Environ 67:101–115

    Google Scholar 

  • Thiel DH van (1983) Ethanol: its adverse effects upon the hypothalamic-pituitary-gonadal axis. J Lab Clin Med 101:21

    Google Scholar 

  • Tiwari I, Timm P, Rothe P (1985) Lead poisoning and euthyroid hyperthyroxinaemia. Lancet 29:1508–1509

    Google Scholar 

  • Wägar G, Sakari WDO, Kurppa K, Wambugu AV, Tuppurainen M, Froseth B (1985) Lead exposure and thyroid function. Acta Endocr [Suppl 270] 109

    Google Scholar 

  • Wildt K, Eliasson R, Berlin M (1983) Effects of occupational exposure to lead on sperm and semen. In: Clarkson TW, Nordberg GF, Sager PR (eds) Reproductive and developmental toxicity of metals. Plenum Publ Co, New York, pp 279–300

    Google Scholar 

  • Wu SH, Oldfield JE, Muth OH, Whanger PD, Weswig PH (1973) Effect of selenium, vitamin E and antioxidants on testicular function in rats. Biol Reprod 8:625–629

    Google Scholar 

  • Wu ASH, Oldfield JE, Shull LR, Cheeke PR (1979) Specific effect of selenium deficiency on rat sperm. Biol Reprod 20:793–798

    Google Scholar 

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Gustafson, Å., Hedner, P., Schütz, A. et al. Occupational lead exposure and pituitary function. Int. Arch Occup Environ Heath 61, 277–281 (1989). https://doi.org/10.1007/BF00381426

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  • DOI: https://doi.org/10.1007/BF00381426

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