Summary
The effect of physical workload on the retention and metabolism of organic solvents has been studied. The relationships obtained contain the alveolar ventilation and a new parameter M (apparent metabolic clearance) determined by the blood solubility of the solvent and the metabolic clearance of the body. It is seen that the influence of physical workload on retention and metabolism is maximal for those compounds which are the most soluble in blood and/or metabolized most significantly (high value of M). These results were then used in the context of repeated exposures and discussed with regards to the control of industrial exposure to organic solvents. Furthermore, a differentiated reduction of the TLV concentrations is proposed according to the intensity of the work carried out and the nature of the solvent. The results thus obtained can be used as a guide in exposure monitoring and indicate in which cases physical effort becomes a determinant or insignificant factor.
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Åstrand, I.: Uptake of solvents in the blood and tissues of man. A review. Scand.J.work environm. & hlth 1, 199–218 (1975)
Åstrand, I., Ehrner-Samuel, H., Kilbom, A., Övrum, P.: Toluene exposure. I. Concentration in alveolar air and blood at rest and during exercise. Work environm.hlth 9, 119–130 (1972)
Åstrand, I., Kilbom, A., Wahlberg, I., Övrum, P.: Methylchloroform exposure. I. Concentration in alveolar air and blood at rest and during exercise. Work environ.hlth 10, 69–81 (1973)
Brown, J.R., Crowden, G.P.: Energy expenditure ranges and muscular work grades. Brit.J.industr.Med. 20, 277–283 (1963)
Conney, A.H.: Environmental factors influencing drug metabolism. In: Fundamentals of drug metabolism and drug disposition (B.N. La Du, H.G. Mandel, E.L. Way, eds.), pp.253–265. Baltimore: Williams and Wilkins 1972
DiVincenzo, G.D., Yanno, F.J., Astill, B.D.: Human and canine exposures to methylene chloride vapor. Amer.Ind.Hyg.Assoc.J. 33, 125–135 (1972)
Droz, P.O., Fernandez, J.G.: Unpublished results (1975)
Droz, P.O., Fernandez, J.G.: Concentrations of solvents in arterial blood and end-tidal air. Partition coefficient and blood-breath ratio (to be published)
Fernandez, J.G., Caperos, J.R.: Etude expérimentale sur des sujets humains de l'absorption et de l'excrétion pulmonaire du styrene. (To be published)
Fernandez, J.G., Caperos, J.R.: Etude expérimentale sur des sujets humains de l'absorption et de l'excrétion pulmonaire du toluéne. (To be published)
Fernandez, J.G., Droz, P.O.: Absorption et élimination pulmonaire de l'acétate d'éthyle. Etude expérimentale sur des sujets humains. Arch.Mal.Prof. 35, 953–961 (1974)
Fernandez, J.G., Humbert, B.E., Droz, P.O., Caperos, J.R.: Exposition au trichloréthylène. Bilan de l'absorption, de l'excrétion et du métabolisme sur des sujets humains. Arch.Mal.Prof. 36, 397–407 (1975)
Hunter, C.G., Blair, D.: Benzene: Pharmacokinetic studies in man. Ann. Occup.Hyg. 15, 193–199 (1972)
Mapleson, W.W.: An electric analogue for uptake and exchange of inert gases and other agents. J.appl.Physiol. 18, 197–204 (1963)
Riley, E.C., Fasset, D.W., Sutton, W.L.: Methylene chloride vapor in expired air of human subjects. Amer.Ind.Hyg.Assoc.J. 27, 341–348 (1966)
Saltzman, B.E.: Significance of sampling time in air monitoring. Journal of the air pollution control association 20, 660–665 (1970)
Zenz, C., Berg, B.A.: The influence of submaximal work on solvent uptake. J.occup.Med. 12, 367–369 (1970)
Zielhuis, R.L.: Threshold limit values and total work load. J.occup.Med. 13, 30–34 (1971)
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Droz, P.O., Fernandez, J.G. Effect of physical workload on retention and metabolism of inhaled organic solvents a comparative theoretical approach and its applications with regards to exposure monitoring. Int. Arch Occup Environ Heath 38, 231–246 (1977). https://doi.org/10.1007/BF00378335
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DOI: https://doi.org/10.1007/BF00378335