Regular ArticleOvarian Luteal Cell Toxicity of Ethylene Glycol Monomethyl Ether and Methoxy Acetic Acidin Vivoandin Vitro☆
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Ethylene oxide derived glycol ethers: A review of the alkyl glycol ethers potential to cause endocrine disruption
2022, Regulatory Toxicology and PharmacologyCitation Excerpt :Of the other identified studies, again there was nothing noted beyond the consistent reports of testicular toxicity. The only other finding reported of note was that of Davis et al. (1997) where suppression of female cyclicity and elevation of serum progesterone level was noted in a satellite study to the main study performed. Only a single dose of 300 mg/kgbw was administered to these animals and it was found to cause an up to 5 fold increase in progesterone level; serum levels of estradiol, follicle stimulating hormone, luteinizing hormone and prolactin remained at baseline levels.
Toxicologic pathology of the reproductive system
2022, Reproductive and Developmental ToxicologyHepatic oxidative stress, up-regulation of pro-inflammatory cytokines, apoptotic and oncogenic markers following 2-methoxyethanol administrations in rats
2020, Biochemistry and Biophysics ReportsCitation Excerpt :In male rats, both 2-ME and 2-EE altered testicular function by lowering the number of spermatocytes and spermatids as well as degeneration of spermatocytes [8]. These compounds also caused a toxic effect majorly on ovarian luteal cells in female rats [9]. Occupational exposure to 2-EE and 2-ME had been reported to reduce sperm count in men and disturbance in the menstrual cycle in women [10].
Ovarian Toxicology
2018, Comprehensive Toxicology: Third EditionOvary
2017, Boorman's Pathology of the Rat: Reference and Atlas
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This report was made possible by Grant ES00233 from the National Institute of Environmental Health Sciences, NIH.
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To whom correspondence should be addressed at NIEHS, MD B3-06, P.O. Box 12233, RTP, NC 27709. Fax: (919) 541-7666. E-mail: Davis1@ NIEHS.NIH.GOV.