Regular ArticleReproductive Toxicity and Growth Effects in Rats Exposed to Lead at Different Periods during Development
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Association of blood metal exposure with age at menarche in Korean women: KNHANES (2008–2017)
2024, International Journal of Hygiene and Environmental HealthPubertal lead exposure affects ovary development, folliculogenesis and steroidogenesis by activation of IRE1α-JNK signaling pathway in rat
2023, Ecotoxicology and Environmental SafetySodium para-aminosalicylic acid ameliorates brain neuroinflammation and behavioral deficits in juvenile lead-exposed rats by modulating MAPK signaling pathway and alpha-synuclein
2023, Toxicology LettersCitation Excerpt :The reasons may be due PAS’s short t1/2 (34 min) in plasma, thus, only high doses of PAS might be able maintain a stable concentration of PAS in the blood and allow sufficient levels PAS and its major metabolite AcPAS to cross the BBB into the brain parenchyma (Hong et al., 2011). Numerous studies have shown that early-life Pb exposure has negative effect on the growth development (Ronis et al., 1996; Liu et al., 2019). In the present study, we found that the body-weight gain of Pb-exposed rats was significantly slower than that in the control group, suggesting that Pb exposure during juvenile period delayed growth development.
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