Regular ArticlePharmacokinetics of 2-Methoxyethanol and 2-Methoxyacetic Acid in the Pregnant Mouse: A Physiologically Based Mathematical Model
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Physiologically based pharmacokinetic models in reproductive and developmental toxicology
2022, Reproductive and Developmental ToxicologyPlacental transfer of xenobiotics in pregnancy physiologically-based pharmacokinetic models: Structure and data
2019, Computational ToxicologyCitation Excerpt :Animal-based experimental methods are the main information supplier of placental diffusional transfer rates in pPBPK modeling studies (Tables 1 and 2), mainly as they are easy to operate with low inter-individual variation because of inbred animals, they offer to study placental transfer at different gestation ages and are whole body system which integrate the physiological changes due to pregnancy. In vivo animal data were used both in animal [50,58,79,86,128,129] and human [73,130] pPBPK models and most of the time for environmental chemicals. The experiments were conducted in different animal species (rats, mice, guinea pig, rabbits, sheep, pig, non-human primates etc.).
Physiologically based pharmacokinetic models in the risk assessment of developmental neurotoxicants
2018, Handbook of Developmental NeurotoxicologyPharmacokinetics and PBPK Models
2018, Comprehensive Toxicology: Third EditionPhysiologically based pharmacokinetic models in reproductive and developmental toxicology
2017, Reproductive and Developmental ToxicologyGestational influences on the pharmacokinetics of gestagenic drugs: A combined in silico, in vitro and in vivo analysis
2011, European Journal of Pharmaceutical SciencesCitation Excerpt :Experimental observations accounting for the esterases mediated degradation of the gestagenic drug indicate that the esterase activity is induced during pregnancy as well (data on file). Mainly based on the PBPK model by O’Flaherty et al. (1992) several PBPK models describing drug disposition during pregnancy in different species accounting for drug disposition in the mother and fetus have been developed (Clarke et al., 1993; Terry et al., 1995; Ward et al., 1997; Hays et al., 2000). All of the models consider changes in organ weights and/or blood flow rates in the mother as well as growth of the fetus (O’Flaherty et al., 1992; Clarke et al., 1993; Terry et al., 1995; Ward et al., 1997; Hays et al., 2000).