Regular ArticleSynergistic Neurotoxic Effects of Styrene Oxide and Acrylamide: Glutathione-Independent Necrosis of Cerebellar Granule Cells
References (0)
Cited by (22)
Mitochondrial dysfunction promotes the necroptosis of Purkinje cells in the cerebellum of acrylamide-exposed rats
2023, Food and Chemical ToxicologyCitation Excerpt :Several lines of evidence suggest that changes in Purkinje neurons occur prior to the onset of neurological toxicity, and the damage to Purkinje appears to be selective because other neurons in the brain or spinal cord do not exhibit soma death and dendritic degeneration (Martin et al., 1998; Rossi et al., 1995; Spencer and Schaumburg, 1975). In addition, some studies have also found that ACR exposure led to the reduction of cerebellar granule cells (Beiswanger et al., 1993). Therefore, investigating the effects and underlying mechanisms of ACR on the cerebellum, especially Purkinje cells, can contribute to understanding the neurotoxicity of ACR.
Analysis of oxidative stress in SK-N-MC neurons exposed to styrene-7,8-oxide
2005, Toxicology in VitroCitation Excerpt :Brain dopamine depletion has been reported upon exposure to styrene or styrene metabolites in experimental studies (Mutti et al., 1984b, 1988), and the dopaminergic system has been suggested as a specific target for styrene neurotoxicity both in humans (Mutti et al., 1984a; Arfini et al., 1987; Mutti and Franchini, 1987) and laboratory animals (Mutti et al., 1984b, 1988). SO at high doses has been shown to be neurotoxic in animals and using in vitro models (Katoh et al., 1989; Trenga et al., 1991; Kohn et al., 1995; Beiswanger et al., 1993; Chakrabarti, 1999) and the mechanisms by which it acts are still unclear. SO exposure induces depletion of cells in rat brain and is cytotoxic to neurons in vitro (Kohn et al., 1995; Dypbukt et al., 1992).
Behavioral and biochemical effects of glutathione depletion in the rat brain
2001, Brain Research BulletinCitation Excerpt :However, the effects of in vivo GSH depletion on cognitive function have been scarcely explored so far. To assess this issue, short-term spatial and inhibitory learning was studied in rats treated with diethylmaleate (DEM), which directly conjugates with GSH and transiently decreases GSH tissue level [7,47]. DEM has been shown to induce in vitro radical oxygen species accumulation and protein damage [22].