Regular ArticleEstimation of Dermal Absorption Using the Exponential Saturation Model☆,☆☆
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Cited by (19)
Pharmacokinetics of aminomethylpropanol in rats following oral and a novel dermal study design
2008, Food and Chemical ToxicologyDermal absorption of 2,4-D: A review of species differences
2005, Regulatory Toxicology and PharmacologyDi-alkyl phosphate biomonitoring data: Assessing cumulative exposure to organophosphate pesticides
2003, Regulatory Toxicology and PharmacologyCould pesticide toxicology studies be more relevant to occupational risk assessment?
2001, Annals of Occupational HygieneCitation Excerpt :Currently, skin residues remaining after washing the treatment site 8–10 h following dose application are assumed to be bioavailable at 24 h when many dermal absorption studies are terminated. An exponential saturation model for estimating dermal absorption was used to compare the calculated rat dermal absorption for five pesticides with and without the direct addition of bound skin residues (Thongsinthusak et al., 1999b). The study indicated that the bound skin residues were frequently not bioavailable.
Refinement of risk assessment of dermally and intermittently exposed pesticide workers: A critique
2001, Annals of Occupational HygieneCitation Excerpt :In conclusion, insight in dose accumulation, effects of repeated exposure and assessment of relevant compounds is considered valuable for occupational risk assessment, in particular for the harvesters (re-entry workers). Dermal absorption studies ought to provide information on the systemic available dose, and as such address the fate of the skin residues (Thongsinthusak et al., 1999; De Heer et al., 1999; Ross et al., 2001). Although this is recognised there still remains some debate on how to use these dermal absorption data in risk assessment.
Conservatism in pesticide exposure assessment
2000, Regulatory Toxicology and Pharmacology
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The opinions expressed in this article represent the views of the authors and do not necessarily reflect the views and policies of the State of California. Mention of trade names or commercial products does not constitute endorsement or recommendation for use.
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W. M. Draper
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To whom correspondence should be addressed at Department of Pesticide Regulation, California Environmental Protection Agency, 830 K Street, Sacramento, CA 95814. Fax: (916) 445-4280. E-mail:[email protected].