IIPs* | Pulmonary sarcoidosis* | Silicosis† | ||||
Exposure to RCS | Cases | IRR (95% CI)‡ | Cases | IRR (95% CI)‡ | Cases | IRR (95% CI)‡ |
Cumulative exposure (μg/m3-years) | ||||||
0 | 14 972 | 1 | 5527 | 1 | 369 | 1 |
<43.6 | 612 | 1.04 (0.96 to 1.13) | 397 | 1.30 (1.17 to 1.44) | 29 | 1.45 (0.99 to 2.13) |
43.6–153.1 | 831 | 1.15 (1.07 to 1.23) | 332 | 1.58 (1.41 to 1.76) | 79 | 1.86 (1.45 to 2.39) |
153.2–1300 | 1454 | 1.14 (1.08 to 1.21) | 414 | 1.61 (1.45 to 1.78) | 96 | 2.95 (2.31 to 3.76) |
Per 50 µg/m3-years, including non-exposed | 1.03 (1.02 to 1.03) | 1.06 (1.04 to 1.07) | 1.20 (1.17 to 1.23) | |||
Per 50 µg/m3-years, excluding non-exposed§ | 1.03 (1.01 to 1.04) | 1.03 (1.01 to 1.05) | 1.16 (1.12 to 1.20) | |||
Highest attained exposure (μg/m3)¶ | ||||||
0 | 14 972 | 1 | 5527 | 1 | 369 | 1 |
<13.8 | 726 | 1.11 (1.03 to 1.20) | 486 | 1.34 (1.22 to 1.47) | 27 | 2.31 (1.55 to 3.45) |
13.8–22.4 | 491 | 1.13 (1.03 to 1.23) | 199 | 1.65 (1.43 to 1.90) | 40 | 2.45 (1.76 to 3.40) |
22.5–105.4 | 1680 | 1.12 (1.06 to 1.18) | 458 | 1.57 (1.42 to 1.74) | 137 | 2.34 (1.91 to 2.86) |
Per 5 µg/m3, including non-exposed | 1.03 (1.02 to 1.03) | 1.05 (1.04 to 1.07) | 1.18 (1.16 to 1.21) | |||
Per 5 µg/m3, excluding non-exposed§ | 1.04 (1.02 to 1.05) | 1.02 (1.00 to 1.04) | 1.23 (1.19 to 1.27) | |||
Duration (years)¶ | ||||||
0 | 14 972 | 1 | 5527 | 1 | 369 | 1 |
1–2 | 428 | 1.06 (0.96 to 1.17) | 241 | 1.23 (1.08 to 1.41) | 43 | 2.24 (1.63 to 3.07) |
3–8 | 929 | 1.15 (1.08 to 1.23) | 383 | 1.43 (1.29 to 1.59) | 89 | 2.29 (1.81 to 2.90) |
9–39 | 1540 | 1.12 (1.06 to 1.18) | 519 | 1.67 (1.52 to 1.83) | 72 | 2.54 (1.94 to 3.34) |
Per 5 years, including non-exposed | 1.03 (1.01 to 1.05) | 1.17 (1.14 to 1.20) | 1.33 (1.22 to 1.44) | |||
Per 5 years, excluding non-exposed§ | 1.00 (0.97 to 1.03) | 1.10 (1.05 to 1.14) | 1.09 (0.94 to 1.25) |
*Followed from 1994 to 2015, 5 100 706 workers.
†Followed from 1977 to 2015, 5 439 728 workers.
‡Adjusted for age, sex, calendar year, education, probability of smoking, connective tissue disease, cancer and medications.
§For silicosis: not adjusted for education.
¶For silicosis: all analyses for this metric are not adjusted for education.