Table 4

Crude and adjusted Cox regression models assessing association between long working hours and stroke

	Ischaemic stroke		Haemorrhagic stroke
	Crude ORs (95% CI)	Adjusted ORs* (95% CI)	Crude ORs (95% CI)	Adjusted ORs* (95% CI)
Age (years)	1.08 (1.06 to 1.10)	1.08 (1.06 to 1.10)	1.10 (1.06 to 1.12)	1.08 (1.05 to 1.12)
Body mass index (kg/m²)	1.06 (1.03 to 1.09)	1.01 (0.97 to 1.05)	1.02 (0.96 to 1.08)	0.95 (0.88 to 1.02)
Sex
Female	Ref		Ref
Male	2.17 (1.51 to 3.11)	1.91 (1.25 to 2.90)	1.13 (0.66 to 1.93)	0.83 (0.44 to 1.55)
High blood pressure diagnosed
No	Ref		Ref
Yes	2.34 (1.56 to 3.50)	0.87 (0.54 to 1.41)	2.66 (1.44 to 4.88)	1.47 (0.74 to 2.93)
Diabetes diagnosed
No	Ref		Ref
Yes	5.09 (2.74 to 9.46)	2.97 (1.50 to 5.89)	1.10 (0.15 to 8.02)	0.64 (0.09 to 4.72)
Familial history of cardiovascular diseases
No	Ref		Ref
Yes	1.32 (0.79 to 2.20)	1.09 (0.65 to 1.86)	1.11 (0.47 to 2.59)	0.89 (0.38 to 2.11)
Dyslipidaemia diagnosed
No	Ref		Ref
Yes	2.94 (1.95 to 4.45)	1.13 (0.65 to 1.86)	3.33 (1.78 to 6.21)	1.66 (0.83 to 3.33)
Smoking
Not smoker	Ref		Ref
Current/former smoker<30 pack-years	1.07 (0.74 to 1.56)	0.94 (0.63 to 1.39)	1.37 (0.74 to 2.52)	1.59 (0.82 to 3.08)
Current/former smoker≥30 pack-years	3.45 (1.97 to 6.04)	1.68 (0.93 to 3.02)	7.18 (3.36 to 15.33)	4.54 (1.95 to 10.59)
Occupation
High-skilled white-collar jobs	Ref		Ref
Self-employed/chief executive officer, professional jobs	0.98 (0.63 to 1.52)	0.94 (0.59 to 1.50)	0.62 (0.33 to 1.17)	0.54 (0.28 to 1.05)
Low-skilled white-collar jobs	0.89 (0.55 to 1.44)	1.29 (0.78 to 2.15)	0.40 (0.18 to 0.90)	0.47 (0.20 to 1.11)
Blue-collar jobs	1.74 (1.03 to 2.94)	1.27 (0.71 to 2.27)	0.52 (0.18 to 1.50)	0.55 (0.19 to 1.63)
Long working hours exposure
<10 years	Ref		Ref
≥10 years	1.61 (1.04 to 2.50)	1.00 (0.63 to 1.61)	2.57 (1.41 to 4.70)	1.91 (1.00 to 3.66)

Significant OR are highlighted in bold.
*Multivariable models are adjusted for age, body mass index, high blood pressure, diabetes, dyslipidaemia, smoking and occupation.