Results of the adjusted multivariable regression analyses (sensitivity analyses) including the current manual work status and the cumulative manual work exposure
| Predictors | Current manual work analysis | Dose–response analysis | ||||
| DD | DD | |||||
| OR | 95% CI | P value | OR | 95% CI | P value | |
| Manual work status | 1.26 | 1.10 to 1.45 | 0.001 | NA | NA | NA |
| Cumulative manual work exposure | NA | NA | NA | 1.08 | 1.01 to 1.16 | 0.029 |
| Age | 1.07 | 1.06 to 1.08 | <0.001 | 1.06 | 1.05 to 1.07 | <0.001 |
| Sex (m) | 3.51 | 3.05 to 4.04 | <0.001 | 3.00 | 2.48 to 3.65 | <0.001 |
| DM (y) | 2.09 | 1.71 to 2.53 | <0.001 | 2.39 | 1.81 to 3.11 | <0.001 |
| Smoker (y) | 1.11 | 0.99 to 1.24 | 0.064 | 1.05 | 0.90 to 1.22 | 0.506 |
| Alcohol intake | ||||||
| (Never) | 1.16 | 0.83 to 1.60 | 0.374 | 0.90 | 0.54 to 1.44 | 0.658 |
| (Special occasions only) | 0.98 | 0.73 to 1.32 | 0.915 | 1.00 | 0.66 to 1.50 | 0.995 |
| (1–3 times a month) | 1.10 | 0.88 to 1.38 | 0.416 | 1.04 | 0.77 to 1.44 | 0.801 |
| (1–2 times a week) (ref) | ||||||
| (3–4 times a week) | 1.25 | 1.01 to 1.57 | 0.046 | 1.25 | 0.93 to 1.72 | 0.151 |
| (Almost daily) | 1.48 | 1.19 to 1.86 | <0.001 | 1.54 | 1.14 to 2.11 | 0.006 |
| Metabolic factors | ||||||
| Triglycerides | 1.06 | 1.00 to 1.12 | 0.038 | 1.08 | 1.00 to 1.17 | 0.050 |
| LDL | 1.02 | 0.96 to 1.09 | 0.507 | 0.98 | 0.89 to 1.08 | 0.682 |
| HDL | 1.80 | 1.51 to 2.14 | <0.001 | 1.48 | 1.15 to 1.90 | 0.002 |
| BMI | 0.94 | 0.93 to 0.96 | <0.001 | 0.94 | 0.92 to 0.96 | <0.001 |
| Hypertension | 1.23 | 1.09 to 1.38 | 0.001 | 1.23 | 1.04 to 1.46 | 0.017 |
| TDI | 1.01 | 0.99 to 1.03 | 0.489 | 1.00 | 0.98 to 1.03 | 0.797 |
| Respiratory disease | 1.07 | 0.92 to 1.24 | 0.361 | 1.09 | 0.88 to 1.33 | 0.428 |
DD, Dupuytren’s disease; LDL, low-density lipoprotein; HDL, high-density lipoprotein; BMI, body mass index; DM, diabetes mellitus; TDI, Townsend Deprivation Index.