Characteristic | Cases (n=494) | % | Controls (n=466) | % |
Median age in years (IQR) | 76 (71–81) | 74 (69–79) | ||
Ethnicity | ||||
White | 479 | 97 | 449 | 96 |
Asian/Asian British | 11 | 2 | 8 | 2 |
Black/African | 2 | 0 | 7 | 2 |
Mixed/other | 2 | 0 | 2 | 0 |
Social class* | ||||
1 | 36 | 7 | 39 | 8 |
2 | 57 | 12 | 61 | 13 |
3 | 78 | 16 | 74 | 16 |
4 | 50 | 10 | 51 | 11 |
5 | 94 | 19 | 97 | 21 |
6 | 114 | 23 | 89 | 19 |
7 | 65 | 13 | 55 | 12 |
Smoking | ||||
Current smoker | 10 | 2 | 30 | 6 |
Ever smoked | 373 | 76 | 327 | 70 |
Median pack years (IQR) | 21 (10–38) | 21 (9–36) | ||
mMRC† | ||||
0 | 35 | 7 | 254 | 55 |
1 | 94 | 19 | 65 | 14 |
2 | 165 | 33 | 80 | 17 |
3 | 172 | 35 | 65 | 14 |
4 | 28 | 6 | 2 | 0 |
rs35705950 genotype | n=464 | n=438 | ||
GG | 183 | 39 | 336 | 77 |
GT | 248 | 53 | 97 | 22 |
TT | 33 | 7 | 5 | 1 |
*Participants were assigned to National Statistics Socio-Economic analytic classes (NS-SEC) provided by the Office of National Statistics on the basis of their occupations. The seven classes used were: 1. higher managerial, administrative and professional occupations; 2. lower managerial, administrative and professional occupations; 3. intermediate occupations; 4. small employers and own account workers; 5. lower supervisory and technical occupations; 6. semi-routine occupations; 7. routine occupations. Further details are provided in the online supplemental file 1.
†mMRC (modified Medical Research Council) dyspnoea scale. 0. not troubled with breathlessness except with strenuous exercise; 1. troubled by shortness of breath when hurrying on the level or walking up a slight hill; 2. walks slower than people of the same age on the level because of breathlessness or has to stop for breath when walking at own pace on the level; 3. stops for breath after walking about 100 yards or after a few minutes on the level; 4. too breathless to leave the house or breathless when dressing or undressing.19