Table 3

Association between cumulative exposures (per intensity-year) and decline in FEV1 (mL) in three studies included in systematic review and meta-analysis


Occupational exposures
Authors, years and cohortMeta-analysis (β-coefficient)
Alif et al.1 (2019) (TAHS cohort)de Jong et al.2 (2014) (VVS)Lytras et al. 29 (2020) (ECRHS cohort)Lytras et al. 29 (2020) (SAPALDIA cohort)
Biological dust0.1 (−0.04 to 0.3)−0.02 (−0.04 to 0.00)−0.39 (−1.13 to 0.31) 0.81 (−1.59 to −0.05)* Fixed−0.02 (−0.04 to −0.00)*
Random−0.09 (−0.24 to 0.06)
Mineral dust0.1 (−0.1 to 0.2)−0.01 (−0.04 to 0.01)−0.39 (−0.96 to 0.20)−0.5 (−1.22 to 0.21)Fixed−0.01 (−0.04 to 0.01)
Random−0.06 (−0.17 to 0.05)
Gases/fumes−0.1 (−0.3 to −0.1)*−0.02 (−0.05 to 0.01)−0.10 (−0.62 to 0.43)−0.23 (−0.89 to 0.42)Fixed−0.03 (−0.06 to 0.00)
Random−0.03 (−0.06 to 0.00)
VGDF−0.03 (−0.14 to 0.07)−0.02 (−0.04 to 0.00)*−0.10 (−0.51 to 0.32)−0.38 (-0.87 to 0.12)Fixed−0.02 (−0.04 to −0.00)*
Random−0.02 (−0.04 to −0.00)*
Fungicides0.2 (−0.2 to 0.5)−0.03 (−0.05 to −0.01)*−1.62 (−3.10 to −0.14)*0.17 (−1.45 to 1.75)Fixed−0.03 (−0.05 to −0.01)*
Random−0.14 (−0.43 to 0.14)
Herbicides0.3 (−0.1 to 0.7)−0.02 (−0.04 to 0.01)−2.74 (−4.82 to −0.54)*0.23 (−1.45 to 1.88)Fixed−0.02 (−0.05 to 0.00)
Random−0.25 (−0.69 to 0.20)
Insecticides0.1 (−0.2 to 0.4)−0.03 (−0.05 to −0.01)*−1.56 (−3.03 to −0.11)*0.04 (−1.03 to 1.10)Fixed−0.03 (−0.05 to −0.01)*
Random−0.08 (−0.28 to 0.12)
Aromatic solvents−0.6 (−1.0 to −0.3)*NA0.57 (−0.56 to 1.70)−0.59 (−1.97 to 0.78)Fixed−0.60 (−0.92 to −0.27)*
Random−0.60 (−0.92 to −0.27)*
Chlorinated solvent−0.1 (−0.3 to 0.1)NA−0.48 (−1.34 to 0.37)−0.50 (−1.50 to 0.50)Fixed−0.13 (-−0.32 to 0.06)
Random−0.13 (−0.32 to 0.06)
Metals−0.1 (−0.2 to 0.1)NA−0.51 (−1.28 to 0.27)−0.75 (−1.71 to 0.21)Fixed−0.13 (-0.27 to 0.02)
Random−0.23 (−0.57 to 0.10)
  • Data are presented as coefficients (95% confidence intervals).

  • *Statistically significant associations.

  • ECRHS, European Community Respiratory Health Survey Study; NA, Not Applicable; SAPALDIA, Swiss Cohort Study on Air Pollution and Lung Disease in Adults; TAHS, Tasmanian Longitudinal Health Study; VGDF, Vapours, Dust, Gases and Fumes ; VVS, Vlagtwedde-Vlaardingen Study.