Canonical pathways enriched among the genes differentially methylated between baseline and follow-up
| Ingenuity canonical pathways* | Total genes in pathway (n) | q value for enrichment | Genes in pathway with less methylation at follow-up (n) | Genes in pathway with more methylation at follow-up (n) |
| Molecular mechanisms of cancer | 437 | 0.0011 | 12 | 11 |
| Colorectal cancer metastasis signalling | 262 | 0.0011 | 11 | 6 |
| ERBB signalling | 93 | 0.0044 | 5 | 4 |
| UVB-induced MAPK signalling | 51 | 0.0044 | 3 | 4 |
| Reelin signalling in neurons | 125 | 0.0069 | 5 | 5 |
| Production of nitric oxide and reactive oxygen species in macrophages | 187 | 0.0098 | 6 | 6 |
*These pathways were identified with IPA software (Qiagen). Pathways significantly enriched at a cut-off of q<0.05 are shown here.