Table 4

Incidence of head and neck cancer after exclusion of subjects with a laryngeal cancer according to asbestos exposure and smoking status in the ‘CT-scan sample’ (Cox Models, N=4784–68 277 subjects years)

Cancer of the head and neck after exclusion of subjects with a laryngeal cancer
NumberUnivariate modelFinal model adjusted for smoking, CEI* and TSFE†
N‡HR(95% CI)P valueHR(95% CI)P value
Smoking status (baseline)
Never smokers128610Ref <0.001 Ref 0.03
Former smokers2838120.54 (0.23 to 1.24)0.52 (0.22 to 1.21)
Current smokers32172.31 (0.83 to 6.46) 2.21 (0.79 to 6.15)
MD¶33910.41 (0.05 to 3.23)0.40 (0.05 to 3.16)
Pleural plaque (s)
No355422Ref0.50Ref 0.91
Yes123081.19 (0.52 to 2.71)1.05 (0.45 to 2.45)
Asbestos exposure
Duration (years)0.99 (0.95 to 1.02)0.44
(0–20)653Ref0.30
(20–30)9250.58 (0.18 to 1.90)
(30–40)2118160.99 (0.38 to 2.61)
≥40108830.37 (0.09 to 1.54)
CEI* (f.years/mL)
For an increase of 10 f.years/mL 1.03 (1.00 to 1.06) 0.04 1.03 (1.00 to 1.06) 0.03
  • Bold values indicate statistical significance.

  • *CEI: cumulative exposure index to asbestos (f.years/mL).

  • †TSFE: time since first exposure (years).

  • ‡N: overall number of subjects by category.

  • §C: overall number of incident cases of cancer of the head and neck (update 1 July 2019).

  • ¶MD: missing data.