Table 4

Odds of chest imaging findings associated with lung function abnormalities among engineered stone workers from four countries

Lung function abnormality*nComplicated silicosis/PMFGround-glass opacitiesMediastinal/hilar lymphadenopathyGround-glass opacities or lymph node silicosis only
OR (95% CI)P valueOR (95% CI)P valueOR (95% CI)P valueOR (95% CI)P value
Unadjusted
 Restrictive pattern1281.21
(0.53 to 2.77)
0.651.17
(0.41 to 3.33)
0.772.09
(0.73 to 5.99)
0.170.97
(0.37 to 2.57)
0.96
 Obstructive pattern1420.85
(0.37 to 1.96)
0.700.90
(0.31 to 2.65)
0.850.39
(0.17 to 0.93)
0.030.83
(0.31 to 2.25)
0.72
 Mixed pattern1283.52
(1.04 to 11.89)
0.041.09
(0.22 to 5.39)
0.92NENE0.77
(0.16 to 3.73)
0.74
 Reduced TLC1292.48
(1.16 to 5.31)
0.021.36
(0.52 to 3.55)
0.533.93
(1.39 to 11.12)
0.010.98
(0.41 to 2.38)
0.97
 Reduced DLCO1372.49
(1.20 to 5.15)
0.011.21
(0.49 to 3.02)
0.681.75
(0.77 to 4.01)
0.191.02
(0.45 to 2.35)
0.96
Adjusted†
 Restrictive pattern1281.18
(0.51 to 2.71)
0.701.18
(0.41 to 3.36)
0.762.04
(0.71 to 5.87)
0.190.98
(0.37 to 2.59)
0.97
 Obstructive pattern1420.77
(0.32 to 1.83)
0.560.93
(0.32 to 2.77)
0.900.36
(0.15 to 0.86)
0.020.85
(0.31 to 2.33)
0.76
 Mixed pattern1283.77
(1.11 to 12.85)
0.031.08
(0.22 to 5.36)
0.93NENE0.76
(0.16 to 3.71)
0.73
 Reduced TLC1292.45
(1.14 to 5.27)
0.021.37
(0.52 to 3.59)
0.523.86
(1.36 to 10.96)
0.010.99
(0.41 to 2.40)
0.98
 Reduced DLCO1372.24
(1.06 to 4.77)
0.041.23
(0.48 to 3.17)
0.661.59
(0.68 to 3.74)
0.281.03
(0.44 to 2.44)
0.95
  • All participants with mixed spirometry had mediastinal/hilar adenopathy.

  • Bolded values represent odd ratios with significance p<0.05.

  • *The reference group for all comparisons was those with absence of the specified lung function abnormality.

  • †Adjusted for smoking pack-years.

  • DLCO, diffusion capacity of lung for carbon monoxide; NE, not estimable; TLC, total lung capacity.