Incidence of head and neck cancer after exclusion of subjects with a laryngeal cancer according to asbestos exposure and smoking status in the ‘CT-scan sample’ (Cox Models, N=4784–68 277 subjects years)
| Cancer of the head and neck after exclusion of subjects with a laryngeal cancer | ||||||
| Number | Univariate model | Final model adjusted for smoking, CEI* and TSFE† | ||||
| N‡ | C§ | HR(95% CI) | P value | HR(95% CI) | P value | |
| Smoking status (baseline) | ||||||
| Never smokers | 1286 | 10 | Ref | <0.001 | Ref | 0.03 |
| Former smokers | 2838 | 12 | 0.54 (0.23 to 1.24) | 0.52 (0.22 to 1.21) | ||
| Current smokers | 321 | 7 | 2.31 (0.83 to 6.46) | 2.21 (0.79 to 6.15) | ||
| MD¶ | 339 | 1 | 0.41 (0.05 to 3.23) | 0.40 (0.05 to 3.16) | ||
| Pleural plaque (s) | ||||||
| No | 3554 | 22 | Ref | 0.50 | Ref | 0.91 |
| Yes | 1230 | 8 | 1.19 (0.52 to 2.71) | 1.05 (0.45 to 2.45) | ||
| Asbestos exposure | ||||||
| Duration (years) | 0.99 (0.95 to 1.02) | 0.44 | ||||
| (0–20) | 653 | Ref | 0.30 | – | ||
| (20–30) | 925 | 0.58 (0.18 to 1.90) | – | |||
| (30–40) | 2118 | 16 | 0.99 (0.38 to 2.61) | – | ||
| ≥40 | 1088 | 3 | 0.37 (0.09 to 1.54) | – | ||
| CEI* (f.years/mL) | ||||||
| For an increase of 10 f.years/mL | 1.03 (1.00 to 1.06) | 0.04 | 1.03 (1.00 to 1.06) | 0.03 | ||
Bold values indicate statistical significance.
*CEI: cumulative exposure index to asbestos (f.years/mL).
†TSFE: time since first exposure (years).
‡N: overall number of subjects by category.
§C: overall number of incident cases of cancer of the head and neck (update 1 July 2019).
¶MD: missing data.