Enriched gene sets annotated to disease and disease-related functions in IPA among differentially methylated genes comparing baseline to follow-up (q<0.05)
| Disease category | Enriched disease annotations (gene-sets) in this category (n) |
| Cancer, cell cycle, organismal injury and abnormalities | 3 |
| Cancer, dermatological diseases and conditions, organismal injury and abnormalities | 1 |
| Cancer, endocrine system disorders, gastrointestinal disease, organismal injury and abnormalities | 5 |
| Cancer, gastrointestinal disease, organismal injury and abnormalities | 32 |
| Cancer, gastrointestinal disease, organismal injury and abnormalities, tumour morphology | 1 |
| Cancer, haematological disease, immunological disease, organismal injury and abnormalities | 3 |
| Cancer, neurological disease, organismal injury and abnormalities | 19 |
| Cancer, organismal injury and abnormalities | 23 |
| Cancer, organismal injury and abnormalities, reproductive system disease | 4 |
| Cancer, organismal injury and abnormalities, respiratory disease | 5 |
| Cancer, organismal injury and abnormalities, tumour morphology | 1 |
| Cardiovascular disease, cardiovascular system development and function, organ morphology, organismal development, organismal injury and abnormalities, skeletal and muscular disorders | 1 |
| Cardiovascular system development and function, cellular development, cellular growth and proliferation | 1 |
| Cardiovascular system development and function, organ development, organ morphology | 1 |
| Cell cycle | 3 |
| Cell-to-cell signalling and interaction | 1 |
| Cell-to-cell signalling and interaction, haematological system development and function | 1 |
| Cellular development | 1 |
| Cellular development, cellular growth and proliferation, haematological system development and function, haematopoiesis, tissue development | 1 |
| Cellular movement | 4 |
| Cellular movement, nervous system development and function | 1 |
| Connective tissue disorders, inflammatory disease, inflammatory response, organismal injury and abnormalities, skeletal and muscular disorders | 1 |
| Dermatological diseases and conditions, organismal injury and abnormalities | 1 |
| Developmental disorder, hereditary disorder, neurological disease, organismal injury and abnormalities | 1 |
| Gene expression | 6 |
| Haematological system development and function, haematopoiesis | 1 |
| Neurological disease, organismal injury and abnormalities | 1 |
*These gene-sets were identified with IPA software (Qiagen). Summary is shown of enriched gene-sets that fall under broader categories of disease functions. For full list of statistically significant gene-sets, see online supplemental table 3.