Table 5

Death from head and neck cancer after exclusion of death from laryngeal cancer according to asbestos exposure and smoking status in the entire cohort (Cox models, N=12 511–137 901 subjects years)

Cancer of the head and neck after exclusion of death from laryngeal cancer
NumberUnivariate modelFinal model adjusted for smoking, CEI* and TSFE†
N‡HR(95% CI)P valueHR(95% CI)P value
Smoking status (baseline)
Never smokers25632Ref0.002Ref0.0007
Former smokers537592.01 (0.43 to 9.35)1.90 (0.41 to 8.81)
Current smokers742912.15 (2.50 to 58.93)11.99 (2.49 to 57.86)
MD¶383193.30 (0.71 to 15.30)3.48 (0.75 to 16.15)
Asbestos exposure
Duration (years)0.98 (0.95 to 1.02)0.30
(0–20)18257Ref0.80
(20–30)236470.82 (0.28 to 2.40)
(30–40)5422100.59 (0.21 to 1.63)
≥40290050.66 (0.19 to 2.22)
CEI* (f.years/mL)
For an increase to 10 f.years/mL1.03 (1.00 to 1.06)0.031.03 (1.01 to 1.06)0.02
  • Bold values indicate statistical significance.

  • *CEI: cumulative exposure index to asbestos.

  • †TSFE: time since first exposure (years).

  • ‡N: overall number of subjects by category.

  • §C: overall number of deaths from head and neck cancer (update 31 December 2015).

  • ¶MD: missing data.