Table 3

Incidence of head and neck cancer after exclusion of subjects with a laryngeal cancer according to asbestos exposure and smoking status in the entire cohort (Cox models, N=12 685–176 256 subjects years)

Cancer of the head and neck after exclusion of subjects with a laryngeal cancer
NumberUnivariate modelFinal model adjusted for smoking, CEI* and TSFE†
N‡HR(95% CI)P valueHR(95% CI)P value
Smoking status (baseline)
Never smokers261114Ref<0.001Ref<0.001
Former smokers5340291.03 (0.54 to 1.94)1.00 (0.53 to 1.89)
Current smokers735184.32 (2.09 to 8.94)4.27 (2.07 to 8.82)
MD¶3999412.04 (1.11 to 3.73)2.09 (1.14 to 3.84)
Asbestos exposure
Duration (years)0.99 (0.97 to 1.01)0.30
(0–20)184119Ref0.80
(20–30)2413220.96 (0.51 to 1.79)
(30–40)5508410.82 (0.47 to 1.45)
≥402923200.74 (0.39 to 1.43)
CEI* (f.years/mL)
For an increase of 10 f.years/mL1.02 (0.99 to 1.03)0.081.02 (1.00 to 1.04)0.04
  • Bold values indicate statistical significance.

  • *CEI: cumulative exposure index to asbestos (f.years/mL).

  • †TSFE : time since first exposure (years).

  • ‡N: overall number of subjects by category.

  • §C: overall number of incident cases of cancer of the head and neck (update 1 July 2019).

  • ¶MD: missing data.