Table 4

Adjusted* beta-coefficient (β) with 95% CI, trend p value, with Akaike information criterion (AIC), for the relation between butadiene or styrene ppm-years (including person-time with zero monomer exposure), lagged 0, 10 or 20 years, and lymphohaematopoietic cancers (LHC)

Monomer, Form of LHC,
lag period (years)
β95% CITrend p valueAIC
I. Butadiene
All leukaemia
 02.55×10−40.52 to 4.57×10−40.0142384
 102.58×10−40.38 to 4.78×10−40.0222337
 202.63×10−4−0.05 to 5.31×10−40.0552120
Lymphoid leukaemia
 03.81×10−41.05 to 6.58×10−40.007933
 103.73×10−40.78 to 6.68×10−40.013933
 203.00×10−4−0.70 to 6.69×10−40.112868
Myeloid leukaemia
 01.09×10−4−3.01 to 5.18×10−40.6021235
 101.16×10−4−3.33 to 5.66×10−40.6121189
 202.11×10−4−2.90 to 7.11×10−40.4101054
Acute myeloid leukaemia
 0−1.08×10−4−9.12 to 6.97×10−40.793746
 10−0.72×10−4−8.54 to 7.10×10−40.857724
 20−0.14×10−4−8.85 to 8.57×10−40.975641
Non-Hodgkin’s lymphoma
 00.26×10−4−3.73 to 4.25×10−40.8981976
 101.10×10−5−43.61 to 45.80×10−50.9621973
 20−6.18×10−5−67.04 to 54.67×10−50.8421876
Multiple myeloma
 0−0.82×10−4−5.08 to 3.45×10−40.7071056
 10−7.54×10−5−52.81 to 37.74×10−50.7441054
 20−9.77×10−5−64.26 to 44.73×10−50.725955
B-cell malignancy
 01.15×10−4−0.75 to 3.05×10−40.2373785
 101.13×10−4−0.95 to 3.21×10−40.2873779
 200.73×10−4−1.95 to 3.40×10−40.5953517
II. Styrene
Leukaemia
 01.04×10−3−0.26 to 2.33×10−30.1162386
 101.03×10−3−0.38 to 2.45×10−30.1532339
 200.96×10−3−0.82 to 2.74×10−30.2892122
Lymphoid leukaemia
 01.63×10−30.03 to 3.23×10−30.046936
 101.67×10−3−0.06 to 3.40×10−30.058934
 201.43×10−3−0.74 to 3.60×10−30.197869
Myeloid leukaemia
 0−2.36×10−4−32.20 to 27.48×10−40.8771235
 10−4.37×10−4−39.04 to 30.30×10−40.8051189
 20−3.53×10−4−46.45 to 39.40×10−40.8721054
Acute myeloid leukaemia
 0−6.23×10−4−51.03 to 38.56×10−40.785746
 10−4.02×10−4−47.81 to 39.77×10−40.857724
 20−2.72×10−4−54.77 to 49.32×10−40.918641
Non-Hodgkin’s lymphoma
 0−0.23×10−3−2.62 to 2.17×10−30.8541976
 10−3.04×10−4−29.50 to 23.43×10−40.8221973
 20−7.57×10−4−42.45 to 27.30×10−40.6701876
Multiple myeloma
 00.15×10−3−1.55 to 1.85×10−30.8581056
 101.04×10−4−17.61 to 19.70×10−40.9131054
 20−0.52×10−4−23.95 to 22.90×10−40.965955
B-cell malignancy
 05.65×10−4−4.74 to 16.03×10−40.2873785
 105.42×10−4−5.97 to 16.81×10−40.3513779
 203.36×10−4−11.18 to 17.91 x10−40.6513517