Direct age-standardised incidence rates per 100 000 person-years for neurodegenerative conditions among workers in the study cohort, standardising to the 2011 Ontario male population
| Study population | Alzheimer’s disease (2006–2016) | ‘Alzheimer’s and other dementias’ (1999–2016) | Parkinson’s disease (2006–2016) | Parkinsonism (1999–2016) | Motor neuron disease (2006–2016) | Amyotrophic lateral sclerosis (2012–2016) |
| Total workers in the study cohort | 42.9 | 319.1 | 34.6 | 53.2 | 4.3 | 3.6 |
| Workers in non-mining industries | 43.0 | 319.3 | 34.5 | 53.2 | 4.3 | 3.5 |
| Workers in industry of mines (including milling), quarries and oil wells (SIC 04) | 40.8 | 305.5 | 38.5 | 51.6 | 5.2 | 6.3 |
| Workers in non-mining occupations | 42.9 | 319.5 | 34.5 | 53.2 | 4.3 | 3.6 |
| Workers in occupations of mining and quarrying, including oil and gas field (CCDO 77) | 53.0 | 294.0 | 40.9 | 50.8 | 5.5 | 4.9 |
Alzheimer’s disease: At least one record with one diagnostic code (ICD10: G30) in any diagnostic field in DAD or NACRS.
Alzheimer’s and other dementias: At least one record with one diagnostic code (ICD-10 F00, F01, F02, F03, G30) in any diagnostic field in DAD or NACRS or at least two physician encounters with at least one diagnostic code in OHIP (OHIP code 290, 331) within 12 months.
Parkinson’s disease: At least one record with one diagnostic code (ICD10: G20) in any diagnostic field in DAD or NACRS.
Parkinsonism: at least one record with one diagnostic code ICD-10 G20, G21.0-0.4, G21.8-9, G22, F02.3 in any diagnostic field in DAD or NACRS or at least two physician encounters with at least one diagnostic code in OHIP (OHIP code 332) within 12 months.
Motor neuron disease: At least one record with one diagnostic code (ICD10: G12.2) in any diagnostic field in DAD or NACRS.
Amyotrophic later sclerosis: At least one record with one diagnostic code (ICD10: G12.20) in any diagnostic field in DAD or NACRS.
CCDO, Canadian Classification Dictionary of Occupations; DAD, Hospital Discharge Abstract Database; ICD-10, International Classification of Disease, 10th Revision; NACRS, National Ambulatory Care Reporting System; OHIP, Ontario Health Insurance Plan Claims Database; SIC, Standard Industrial Classification.