Table 2

Results calculated with Benchmark Dose Software Version 3 for male and female mouse models.

Tumour typeBMD (mg/kg-day)BMDL (mg/kg-day)CSFa (mg/kg-day)−1 CSFh (mg/kg-day)−1
Male
 Alveolar/bronchiolar carcinoma1.340.780.0640.40
Female
 Multisite*0.0780.0610.825.17
  • Model outputs include the benchmark dose (BMD), benchmark dose level (BMDL), animal cancer slope factor (CSFa) and the calculated human cancer slope factor (CSFh).

  • *Alveolar/bronchiolar carcinoma or adenoma and malignant lymphoma.