ER− | ER+ | |||||||
Cases | Controls | OR* | 95% CI | Cases | Controls | OR* | 95% CI | |
Ever | 1387 | 6935 | 1.00 | 0.93 to 1.06 | 5462 | 26 858 | 1.01 | 0.97 to 104 |
Duration of exposure (years) | ||||||||
1–9 | 1090 | 5437 | 1.00 | 0.93 to 1.07 | 4231 | 20 384 | 1.03 | 0.99 to 1.07 |
10–20 | 201 | 939 | 1.06 | 0.91 to 1.24 | 783 | 3954 | 0.98 | 0.91 to 1.06 |
>20 | 96 | 559 | 0.85 | 0.68 to 1.06 | 448 | 2520 | 0.88 | 0.79 to 0.97 |
Trend test (p value) | 0.75 | 0.46 | ||||||
Cumulative exposure† | ||||||||
>0%–25% | 325 | 1726 | 0.94 | 0.83 to 1.06 | 1380 | 6701 | 1.02 | 0.96 to 1.08 |
>25%–50% | 358 | 1735 | 1.03 | 0.91 to 1.16 | 1421 | 6720 | 1.05 | 0.99 to 1.11 |
>50%–75% | 357 | 1740 | 1.02 | 0.91 to 1.15 | 1383 | 6720 | 1.02 | 0.96 to 1.08 |
>75% | 347 | 1734 | 0.99 | 0.88 to 1.12 | 1278 | 6717 | 0.94 | 0.89 to 1.00 |
Trend test (p value) | 0.73 | 0.84 | ||||||
Timing of first exposure‡ | ||||||||
Prior to first live birth | 758 | 3797 | 1.01 | 0.93 to 1.10 | 3006 | 14 220 | 1.04 | 1.00 to 1.09 |
After first live birth | 457 | 2357 | 0.97 | 0.88 to 1.01 | 1860 | 9694 | 0.99 | 0.94 to 1.04 |
Exposure in last held job§ | ||||||||
No | 1035 | 5251 | 0.98 | 0.91 to 1.06 | 4208 | 20 661 | 1.01 | 0.97 to 1.05 |
Yes | 352 | 1684 | 1.04 | 0.93 to 1.17 | 1254 | 6197 | 1.01 | 0.95 to 1.07 |
*Adjusted for parity, age at first live birth and work-related physical activity.
†Exposure level*years summed over employment history and categorised according to percentiles among the controls.
‡Among parous women.
§Among women with lifetime occupational UVR exposure.
ER, oestrogen receptor; UVR, ultraviolet B radiation.