Effect modification between smoking and employment as painter, stratified by sex and histological subtype
| Stratum | Controls | All lung cancer | AC | SqC | SCLC | ||||||||
| Cases | OR* | 95% CI | Cases | OR* | 95% CI | Cases | OR* | 95% CI | Cases | OR* | 95% CI | ||
| Men | |||||||||||||
| Never smoker and never painter | 4666 | 459 | 1 | Ref | 240 | 1 | Ref | 69 | 1 | Ref | 25 | 1 | Ref |
| Never smoker and ever painter | 87 | 16 | 2.04 | 1.18 to 3.53 | 10 | 2.63 | 1.33 to 5.18 | 3 | 2.35 | 0.72 to 7.64 | 1 | 2.46 | 0.33 to 18.45 |
| Ever smoker and never painter | 13 360 | 14 483 | 11.5 | 10.40 to 12.73 | 3 607 | 6.08 | 5.29 to 6.98 | 6 063 | 28.44 | 22.37 to 36.17 | 2 294 | 31.34 | 21.08 to 46.58 |
| Ever smoker and ever painter | 416 | 631 | 16.48 | 14.05 to 19.33 | 149 | 8.02 | 6.34 to 10.14 | 271 | 41.86 | 31.47 to 55.69 | 103 | 47.14 | 30.01 to 74.05 |
| P value for interaction on multiplicative scale | 0.21 | 0.06 | 0.44 | 0.63 | |||||||||
| Additive interaction: RERI | 3.93 | 1.55 to 6.30 | 0.31 | −2.04 to 2.65 | 12.06 | 4.45 to 19.68 | 14.33 | 1.61 to 27.05 | |||||
| AP | 24% | 12.07 to 35.62 | 4% | −24.94 to 32.63 | 29% | 15.75 to 41.89 | 30% | 11.64 to 49.19 | |||||
| Women | |||||||||||||
| Never smoker and never painter | 3015 | 970 | 1 | ref | 580 | 1 | ref | 127 | 1 | ref | 62 | 1 | ref |
| Never smoker and ever painter | 12 | 9 | 1.58 | 0.64 to 3.88 | 5 | 1.54 | 0.52 to 4.54 | 1 | 1.34 | 0.17 to 10.66 | 0 | – | – |
| Ever smoker and never painter | 2099 | 2751 | 4.72 | 4.28 to 5.21 | 1 027 | 2.83 | 2.50 to 3.20 | 636 | 9.49 | 7.68 to 11.73 | 528 | 13.89 | 10.51 to 18.34 |
| Ever smoker and ever painter | 16 | 26 | 6.12 | 3.19 to 11.74 | 11 | 4.29 | 1.92 to 9.62 | 3 | 4.82 | 1.31 to 17.70 | 6 | 20.41 | 6.91 to 60.29 |
| P value of interaction on multiplicative scale | 0.72 | 0.98 | 0.43 | 0.96 | |||||||||
| Men and Women | |||||||||||||
| Never smoker and never painter | 7681 | 1429 | 1 | ref | 820 | 1 | ref | 196 | 1 | ref | 87 | 1 | ref |
| Never smoker and ever painter | 99 | 25 | 1.58 | 1.01 to 2.48 | 15 | 1.91 | 1.09 to 3.35 | 4 | 1.51 | 0.55 to 4.15 | 1 | 1.24 | 0.17 to 9.03 |
| Ever smoker and never painter | 15 459 | 17 234 | 7.24 | 6.78 to 7.73 | 4 634 | 3.9 | 3.58 to 4.25 | 6 699 | 15.98 | 13.78 to 18.52 | 2 822 | 18.48 | 14.85 to 23.02 |
| Ever smoker and ever painter | 432 | 657 | 10.61 | 9.23 to 12.20 | 160 | 5.34 | 4.35 to 6.56 | 274 | 23.49 | 18.97 to 29.09 | 109 | 28.4 | 20.89 to 38.62 |
| P value of interaction on multiplicative scale | 0.75 | 0.27 | 0.96 | 0.83 | |||||||||
| Additive interaction: RERI | 2.79 | 1.29 to 4.30 | 0.53 | −0.93 to 2.00 | 7.01 | 2.92 to 11.09 | 9.68 | 2.74 to 16.62 | |||||
| AP | 26 % | 14.96 to 37.70 | 10% | −16.24 to 36.20 | 30 % | 17.00 to 42.65 | 34 % | 17.19 to 51.00 | |||||
*Adjusted for centre, age, occupational exposures (list A and B jobs). Models were also adjusted for sex in analyses of men and women combined.
AC, adenocarcinoma; AP, attributable proportion due to interaction; RERI, relative excess risk due to interaction; SCLC, small cell lung cancer; SqC, squamous cell carcinoma.