Table 1

Mendelian randomisation estimates of the associations between five respiratory traits and risk of coal worker’s pneumoconiosis

Exposure	Number of SNPs	IVW method		MR-Egger		Weighted median method		Q_{Heterogeneity}*	P_pleiotropy†
Exposure	Number of SNPs	OR (95% CI)	P value	OR (95% CI)	P value	OR (95% CI)	P value	Q_{Heterogeneity}*	P_pleiotropy†
Lung function	220	0.34 (0.15 to 0.77)	0.010	0.11 (0.02 to 0.61)	0.013	0.21 (0.05 to 0.92)	0.039	0.859	0.142
COPD	65	1.15 (0.69 to 1.94)	0.593	0.97 (0.22 to 4.23)	0.966	0.81 (0.36 to 1.83)	0.616	0.768	0.806
Idiopathic pulmonary fibrosis	12	1.06 (0.74 to 1.5)	0.762	1.37 (0.17 to 10.86)	0.771	0.92 (0.58 to 1.44)	0.705	0.652	0.806
Interstitial lung disease	17	1.07 (0.77 to 1.47)	0.703	1.58 (0.50 to 5.02)	0.453	1.17 (0.80 to 1.7)	0.416	0.083	0.499
Asthma	89	1.36 (0.72 to 2.58)	0.339	13.29 (2.19 to 80.5)	0.006	1.99 (0.76 to 5.22)	0.164	0.373	0.010

The significant associtation of mendelian randomisation was hihlighted in bold.
*P for heterogeneity statistics among different methods.
†Test for horizontal pleiotropy in MR analysis.
COPD, chronic obstructive pulmonary disease; IVW, inverse variance weighted; MR, Mendelian randomisation; MR, Mendelian randomisation; SNP, single nucleotide polymorphism.