Table 1

Mendelian randomisation estimates of the associations between five respiratory traits and risk of coal worker’s pneumoconiosis

ExposureNumber of SNPsIVW methodMR-EggerWeighted median methodQHeterogeneity*Ppleiotropy
OR (95% CI)P valueOR (95% CI)P valueOR (95% CI)P value
Lung function 220 0.34 (0.15 to 0.77) 0.010 0.11 (0.02 to 0.61) 0.013 0.21 (0.05 to 0.92) 0.039 0.859 0.142
COPD651.15 (0.69 to 1.94)0.5930.97 (0.22 to 4.23)0.9660.81 (0.36 to 1.83)0.6160.7680.806
Idiopathic pulmonary fibrosis121.06 (0.74 to 1.5)0.7621.37 (0.17 to 10.86)0.7710.92 (0.58 to 1.44)0.7050.6520.806
Interstitial lung disease171.07 (0.77 to 1.47)0.7031.58 (0.50 to 5.02)0.4531.17 (0.80 to 1.7)0.4160.0830.499
Asthma891.36 (0.72 to 2.58)0.33913.29 (2.19 to 80.5)0.0061.99 (0.76 to 5.22)0.1640.3730.010
  • The significant associtation of mendelian randomisation was hihlighted in bold.

  • *P for heterogeneity statistics among different methods.

  • †Test for horizontal pleiotropy in MR analysis.

  • COPD, chronic obstructive pulmonary disease; IVW, inverse variance weighted; MR, Mendelian randomisation; MR, Mendelian randomisation; SNP, single nucleotide polymorphism.