Table 2

Association details of the identified variants associated with coal worker’s pneumoconiosis risk

SNPPosition (hg19)StageEffect/OtherEAFOR (95% CI)†P value†Phet
rs2609255Chr4:89 811 195GWASG/T0.480.401.35 (1.02 to 1.80)3.80E-02
Interstitial lung diseaseReplication0.480.421.27 (1.10 to 1.48)1.52E-03
Meta1.29 (1.13 to 1.47)1.61E-040.704
rs4651005Chr1:178 719 306GWAST/C0.140.091.69 (1.07 to 2.67)2.60E-02
Lung functionReplication0.140.111.32 (1.05 to 1.66)1.60E-02
Meta1.39 (1.13 to 1.70)1.62E-030.355
rs985256Chr2:201 208 692GWASA/C0.130.180.64 (0.42 to 0.96)3.20E-02
Lung functionReplication0.130.170.75 (0.61 to 0.93)7.76E-03
Meta0.73 (0.61 to 0.88)8.24E-040.469
rs6539952Chr16:86 579 223GWASC/A0.470.391.42 (1.07 to 1.90)1.70E-02
Lung functionReplication0.480.431.24 (1.06 to 1.44)6.64E-03
Meta1.28 (1.11 to 1.46)4.32E-040.405
  • *Derived from the logistic regression model adjusting for significant eigenvectors (GWAS stage), accumulating time of exposure to dust, job type and smoking status if appropriate assuming an additive genetic model

  • †Heterogeneity test for associations between different stages.

  • EAF, effect allele frequency; GWAS, genome-wide association study; SNP, single nucleotide polymorphism.