Table 2

Association details of the identified variants associated with coal worker’s pneumoconiosis risk

SNP	Position (hg19)	Stage	Effect/Other	EAF		OR (95% CI)†	P value†	P_het‡
SNP	Position (hg19)	Stage	Effect/Other	Cases	Controls	OR (95% CI)†	P value†	P_het‡
rs2609255	Chr4:89 811 195	GWAS	G/T	0.48	0.40	1.35 (1.02 to 1.80)	3.80E-02
Interstitial lung disease		Replication		0.48	0.42	1.27 (1.10 to 1.48)	1.52E-03
		Meta				1.29 (1.13 to 1.47)	1.61E-04	0.704
rs4651005	Chr1:178 719 306	GWAS	T/C	0.14	0.09	1.69 (1.07 to 2.67)	2.60E-02
Lung function		Replication		0.14	0.11	1.32 (1.05 to 1.66)	1.60E-02
		Meta				1.39 (1.13 to 1.70)	1.62E-03	0.355
rs985256	Chr2:201 208 692	GWAS	A/C	0.13	0.18	0.64 (0.42 to 0.96)	3.20E-02
Lung function		Replication		0.13	0.17	0.75 (0.61 to 0.93)	7.76E-03
		Meta				0.73 (0.61 to 0.88)	8.24E-04	0.469
rs6539952	Chr16:86 579 223	GWAS	C/A	0.47	0.39	1.42 (1.07 to 1.90)	1.70E-02
Lung function		Replication		0.48	0.43	1.24 (1.06 to 1.44)	6.64E-03
		Meta				1.28 (1.11 to 1.46)	4.32E-04	0.405

*Derived from the logistic regression model adjusting for significant eigenvectors (GWAS stage), accumulating time of exposure to dust, job type and smoking status if appropriate assuming an additive genetic model
†Heterogeneity test for associations between different stages.
EAF, effect allele frequency; GWAS, genome-wide association study; SNP, single nucleotide polymorphism.