Table 3

Joint effect of risk alleles for rs2609255, rs4651005, rs985256 and rs6539952 on pneumoconiosis risk

Number of risk alleleCase (n=905) n (%)Control (n=903) n (%)OR (95% CI)*P value
0–298 (10.83)167 (18.49)
3238 (26.30)257 (28.46)1.56 (1.15 to 1.45)0.00434
4299 (33.04)315 (34.88)1.59 (1.19 to 2.15)0.00205
5175 (19.34)121 (13.40)2.38 (1.70 to 3.36)6.57E-07
6–895 (10.50)43 (4.76)3.72 (2.41 to 5.82)4.86E-09
Trend test2.65×10−10
  • *Derived from the conditional logistic regression model adjusting for smoking status assuming an additive genetic model.