Ref. not exposed | Model 1* | Model 2† | ||||
Coef. | 95% CI | P value | Coef. | 95% CI | P value | |
M en (n=20 234) | ||||||
Types of solvent | ||||||
Gasoline for hand washing | − 0.26 | −0.33 to − 0.18 | < 0.0001 | −0.20†* | −0.28 to − 0.12 | < 0.0001 |
Trichloroethylene | − 0.16 | −0.23 to − 0.10 | 0.0001 | −0.10 | −0.17 to − 0.04 | 0.003 |
White spirit | − 0.28 | −0.34 to − 0.19 | < 0.0001 | −0.21 | −0.29 to − 0.14 | < 0.0001 |
Cellulosic thinner | − 0.36 | −0.46 to − 0.26 | < 0.0001 | − 0.30 | −0.40 to − 0.20 | < 0.0001 |
No. of type of solvents | ||||||
Not exposed | Ref. | – | Ref. | – | ||
Exposed to one type only | − 0.21 | −0.29 to − 0.14 | < 0.0001 | − 0.17 | −0.25 to − 0.09 | < 0.0001 |
Exposed to two different types | − 0.26 | −0.36 to − 0.15 | < 0.0001 | − 0.21 | −0.31 to − 0.10 | 0.0002 |
Exposed to 3different types | − 0.27 | −0.41 to − 0.14 | < 0.0001 | − 0.21 | −0.35 to − 0.08 | 0.002 |
Exposed to four different types | − 0.41 | −0.58 to − 0.25 | < 0.0001 | − 0.35 | −0.51 to − 0.19 | < 0.0001 |
P trend | < 0.0001 | < 0.0001 | ||||
Cumulative exposure time | ||||||
Not exposed | Ref. | – | Ref. | – | ||
1–10 years | − 0.13 | −0.22 to − 0.04 | 0.003 | −0.08 | −0.17 to 0.01 | 0.08 |
10–20 years | − 0.13 | −0.23 to − 0.02 | 0.02 | −0.07 | −0.17 to 0.04 | 0.20 |
>20 years | − 0.38 | −0.47 to − 0.30 | < 0.0001 | − 0.32 | −0.41 to − 0.23 | < 0.0001 |
P trend | < 0.0001 | < 0.0001 | ||||
Delay since last exposure | ||||||
Not exposed | Ref. | – | Ref. | – | ||
>5 years | − 0.21 | −0.27 to − 0.14 | < 0.0001 | −0.15 | −0.22 to − 0.09 | < 0.0001 |
<5 years or currently | − 0.38 | −0.48 to − 0.28 | < 0.0001 | −0.33 | −0.43 to − 0.23 | < 0.0001 |
W o men (n=21 620) | ||||||
Types of solvent | ||||||
Gasoline for hand washing | −0.21 | −0.43 to 0.01 | 0.06 | −0.15 | −0.37 to 0.07 | 0.19 |
Trichloroethylene | −0.02 | −0.18 to 0.14 | 0.82 | 0.03 | −0.14 to 0.19 | 0.73 |
White spirit | − 0.23 | −0.42 to − 0.04 | 0.02 | −0.22 | −0.40 to − 0.03 | 0.02 |
Cellulosic thinner | 0.04 | −0.25 to 0.33 | 0.77 | 0.11 | −0.18 to 0.40 | 0.71 |
No. of type of solvents | ||||||
Not exposed | Ref. | – | Ref. | – | ||
Exposed to one type only | −0.23 | −0.38 to − 0.08 | 0.003 | −0.18 | −0.34 to − 0.03 | 0.02 |
Exposed to two or more different types | 0.04 | −0.20 to 0.27 | 0.77 | 0.06 | −0.17 to 0.30 | 0.59 |
P trend | 0.10 | 0.28 | ||||
Cumulative exposure time | ||||||
Not exposed | Ref. | – | Ref. | – | ||
1–10 years | −0.11 | −0.31 to 0.08) | 0.25 | −0.07 | −0.27 to 0.12 | 0.45 |
>10 years | 0.05 | −0.21 to 0.32 | 0.70 | 0.09 | −0.17 to 0.36 | 0.48 |
>20 years | − 0.38 | −0.63 to − 0.13 | 0.003 | − 0.31 | −0.57 to − 0.06 | 0.01 |
P trend | 0.009 | 0.05 | ||||
Delay since last exposure | ||||||
Not exposed | Ref. | – | Ref. | – | ||
>5 years | −0.12 | −0.29 to 0.05 | 0.18 | −0.07 | −0.24 to 0.10 | 0.40 |
<5 years or currently | − 0.21 | −0.41 to − 0.01 | 0.04 | −0.17 | −0.37 to 0.03 | 0.10 |
*Model 1 adjusted for age, education level, marital status, income, smoking, alcohol consumption, BMI, hypertension, diabetes, cardiovascular disease, respiratory diseases, CESD and FDep09.
†Model 2 adjusted for M1 and night-shift work, repetitive work nd noisy work.
‡The median (IQR) of global cognitive score, from PCA, is 0.08 (−1.02 to 1.15). This is an example of coefficient interpretation for “Coef.=−0.20” for gasoline exposure in model 2, among men: when taking into account all covariates included in model 2, a man, 45–50 years old, has an average global cognitive score of 0.82 compared with 0.62 if exposed. Another example among women, for “Coef=−0.22” interpretation, for white spirit exposure in model 2: a woman, 45–50 years old, has an average global cognitive score of 0.72 compared with 0.50 if exposed.
BMI, body mass index; CESD, Center for Epidemiological Studies–Depression; coef, coefficient; PCA, principal component analysis ; ref, reference.