Peritoneal mesothelioma OR and 90% CI for occupational asbestos exposure from the job-exposure matrix (SYN-JEM), calculated with conditional logistic regression models (set: age category), adjusted for period (2000–2007 and 2008–2015), province of residence, education and residual age within age category, Lombardy, Italy, 2000–2015
| Occupational asbestosexposure | Men | Women | ||||||
| Cases | Controls | OR | 90% CI | Cases | Controls | OR | 90% CI | |
| N (%) | N (%) | N (%) | N (%) | |||||
| Total 2000–2015 | 127 (100) | 1758 (100) | 100 (100) | 563 (100) | ||||
| Total 2000–2007 | 41 (32.3) | 1617 (92.0) | 27 (27.0) | 499 (88.6) | ||||
| Total 2008–2015 | 86 (67.7) | 141 (8.0) | 73 (73.0) | 64 (11.4) | ||||
| Never exposed | 55 (43.3) | 1208 (68.7) | 1.00 | Reference | 83 (83.0) | 510 (90.6) | 1.00 | Reference |
| Ever exposed | 72 (56.7) | 550 (31.3) | 2.05 | 1.39 to 3.01 | 17 (17.0) | 53 (9.4) | 1.62 | 0.79 to 3.27 |
| Duration* | ||||||||
| Never exposed | 55 (43.3) | 1208 (69.3) | 1.00 | Reference | 83 (83.0) | 510 (90.7) | 1.00 | Reference |
| <10 years | 19 (15.0) | 211 (12.1) | 1.46 | 0.85 to 2.53 | 8 (8.0) | 8 (1.4) | 7.44 | 2.40 to 23.1 |
| 10–19 years | 12 (9.4) | 89 (5.1) | 3.36 | 1.71 to 6.61 | 4 (4.0) | 20 (3.6) | 0.43 | 0.12 to 1.56 |
| 20–29 years | 11 (8.7) | 76 (4.4) | 2.14 | 1.03 to 4.45 | 5 (5.0) | 14 (2.5) | 2.05 | 0.61 to 6.89 |
| 30+ years | 30 (23.6) | 159 (9.1) | 2.33 | 1.38 to 3.94 | 0 (0.0) | 10 (1.8) | NC | NC |
| P trend | 0.002 | 0.78 | ||||||
| Duration (per 10 years)* | 1.25 | 1.11 to 1.41 | 0.95 | 0.63 to 1.43 | ||||
| Cumulative exposure* | ||||||||
| Never exposed | 55 (43.3) | 1208 (69.3) | 1.00 | Reference | 83 (83.0) | 510 (90.7) | 1.00 | Reference |
| <0.888 ff/mL-years | 22 (17.3) | 231 (13.3) | 1.66 | 0.98 to 2.82 | 7 (7.0) | 19 (3.4) | 1.94 | 0.70 to 5.36 |
| <3.158 ff/mL-years | 25 (19.7) | 218 (12.5) | 1.63 | 0.96 to 2.76 | 5 (5.0) | 23 (4.1) | 0.99 | 0.31 to 3.13 |
| 3.158+ff/mL-years | 25 (19.7) | 86 (4.9) | 4.21 | 2.36 to 7.50 | 5 (5.0) | 10 (1.8) | 2.65 | 0.71 to 9.87 |
| P trend | <0.001 | 0.28 | ||||||
| Cumulative exposure* (ff/mL-years) | 1.33 | 1.19 to 1.48 | 1.09 | 0.81 to 1.47 | ||||
| Cumulative exposure* (ln(ff/mL-years)) | 2.15 | 1.59 to 2.91 | 1.25 | 0.62 to 2.52 | ||||
| TSFE* | ||||||||
| Never exposed | 55 (43.3) | 1208 (69.1) | 1.00 | Reference | 83 (83.0) | 510 (90.7) | 1.00 | Reference |
| <40 years | 14 (11.0) | 167 (9.6) | 1.37 | 0.72 to 2.61 | 6 (6.0) | 27 (4.8) | 2.40 | 0.92 to 6.38 |
| 40–49 years | 18 (14.2) | 199 (11.4) | 1.33 | 0.73 to 2.42 | 7 (7.0) | 18 (3.2) | 0.97 | 0.31 to 3.04 |
| 50–59 years | 24 (18.9) | 135 (7.7) | 2.87 | 1.62 to 5.06 | 4 (4.0) | 5 (0.9) | 1.87 | 0.38 to 9.07 |
| 60+ years | 16 (12.6) | 39 (2.2) | 4.99 | 2.26 to 11.1 | 0 (0.0) | 2 (0.4) | NC | NC |
| P trend | <0.001 | 0.44 | ||||||
Period 2002–2007 includes cases first diagnosed in 2000–2007 living in five provinces and EAGLE controls enrolled in 2002–2004 living in 216 municipalities of the same five provinces; both series aged 35–79 years. Period 2008–2015 includes cases first diagnosed in 2008–2015 and MISEM controls enrolled in 2014; both series living in any province and aged 20–89 years.
*Missing data for 16 EAGLE controls (15 men and 1 woman) with incomplete job histories.
NC, not calculated; TSFE, time since first exposure.