Table 5

Analyses of cumulative expected lead and ALS case status in women, Denmark, 1982–2013

n=60 105Controls N (%)Cases N (%)OR (95% CI)*aOR (95% CI)†
No lag
 No exposure53 073 (89.27)581 (88.97)1.00 (Ref)1.00 (Ref)
 Ever exposure (µmol/L)‡6379 (10.73)72 (11.03)1.04 (0.81 to 1.33)1.07 (0.83 to 1.38)
 <46.001560 (2.62)20 (3.06)1.18 (0.75 to 1.84)1.17 (0.73 to 1.88)
 46.00–178.501638 (2.76)17 (2.60)0.95 (0.59 to 1.54)1.07 (0.66 to 1.73)
 >178.503181 (5.35)35 (5.36)1.01 (0.72 to 1.43)1.04 (0.73 to 1.48)
 Test for trend1.00 (0.99 to 1.03)1.01 (0.98 to 1.03)
5-year lag
 No exposure53 952 (90.75)590 (90.35)1.00 (Ref)1.00 (Ref)
 Ever exposure (µmol/L)‡5500 (9.25)63 (9.65)1.05 (0.81 to 1.37)1.08 (0.82 to 1.42)
 <46.001590 (2.67)21 (3.22)1.21 (0.78 to 1.88)1.20 (0.76 to 1.91)
 46.00–178.501620 (2.72)18 (2.76)1.02 (0.64 to 1.46)1.06 (0.65 to 1.73)
 >178.202290 (3.85)24 (3.68)0.97 (0.64 to 1.46)1.00 (0.66 to 1.53)
 Test for trend1.00 (0.96 to 1.05)1.00 (0.96 to 1.05)
10-year lag
 No exposure54 274 (91.29)595 (91.12)1.00 (Ref)1.00 (Ref)
 Ever exposure (µmol/L)‡5178 (8.71)58 (8.88)1.03 (0.79 to 1.35)1.04 (0.78 to 1.37)
 <46.001549 (2.61)19 (2.91)1.13 (0.71 to 1.79)1.09 (0.67 to 1.78)
 46.00–178.501555 (2.61)18 (2.76)1.06 (0.66 to 1.71)1.09 (0.67 to 1.78)
 >178.502074 (3.49)21 (3.22)0.93 (0.60 to 1.44)0.95 (0.60 to 1.49)
 Test for trend0.98 (0.93 to 1.04)1.00 (0.93 to 1.05)
  • *Controls were individually matched to cases on age and sex.

  • †Models adjusted for SES and residential location.

  • ‡Cumulative expected exposure=level of exposure*days employed for jobs with >50% probability of exposure.

  • ALS, amyotrophic lateral sclerosis; aOR, adjusted OR; SES, socioeconomic status.