Table 1

Clinical characteristics and response to SIC

CaseABC
Respiratory symptomsLowerUpper and lowerLower
Total IgE, kU/L24383664
Eosinophils, 109/L0.070.250.16
Specific IgE, anhydridesPositive *NegativeNegative
Specific IgE, aeroallergensNegativePositive†Positive‡
Baseline FEV1, L, (% of predicted values), FEV1/FVC3.31 (88%), 0.522.41 (69%), 0.743.90 (106 %), 0.75
Peakflow diurnal variability20%16%Not tested
Methacholine Challenge Test (PD20), µg§268Negative261
Maximum fall in FEV1/hours from challenge start19%/416%/12
24%/24
17%/9
Respiratory symptoms during SICLowerLowerLower
  • *Phthalic anhydride, hexahydrophthalic anhydride, methyltetrahydrophtalic anhydride, positive >0.1 kU/L.

  • Phleum pratensa, Dermatophagoides farinae, Dermatophagoides pteronyssinus, positive >0.35 kU/L.

  • Phleum pratensa, Betula verrucosa, Artemisia vulgaris, Cladosporium herbarium , positive  > 0.35 kU/ L.

  • §Dose of metacholine that results in a 20 % fall in FEV1, positive  < 400  µg .

  • FEV1, forced expiratory flow in 1 s; IgE, immunoglobulin E; SIC, specific inhalation challenge.