Circulating levels of AA and eicosanoids significantly differing in referents and TFW
| Metabolite* | Group | Subgroup | n | Mean (SD) | Median (Q)† | P values‡ | |
| AA§ (invers) | Referents | Never-smokers | 13 | 217.1 (34.5) | 207.0 (164.0, 288.7) | x¶ | y** |
| Daily-smokers | 8 | 249.0 (96.5) | 220.4 (166.1, 480.5) | 0.412 | |||
| TFW | Never-smokers | 14 | 259.8 (81.2) | 235.8 (190.6, 504.0) | 0.086 | 0.002 | |
| Daily-smokers | 24 | 336.6 (124.9) | 298.5 (195.1, 577.3) | <0.001 | |||
| PGD2 (square root) | Referents | Never-smokers | 12 | 24.7 (13.0) | 22.9 (8.1, 48.5) | x¶ | y** |
| Daily-smokers | 8 | 24.4 (14.1) | 23.9 (5.0, 44.8) | 0.852 | |||
| TFW | Never-smokers | 14 | 15.9 (6.3) | 16.0 (7.5, 28.0) | 0.034 | 0.002 | |
| Daily-smokers | 24 | 14.9 (8.3) | 13.9 (4.0, 27.9) | 0.004 | |||
| 15-HETE (log) | Referents | Never-smokers | 13 | 27.4 (9.9) | 25.6 (17.1, 48.4) | x¶ | y** |
| Daily-smokers | 8 | 36.4 (24.6) | 29.9 (8.5, 73.6) | 0.672 | |||
| TFW | Never-smokers | 14 | 36.1 (18.0) | 34.2 (8.5, 79.7) | 0.311 | 0.041 | |
| Daily-smokers | 23 | 48.9 (23.3) | 44.8 (17.1, 83.4) | 0.005 | |||
| 9-HODE (log) | Referents | Never-smokers | 13 | 349.0 (163.2) | 348.9 (117.7, 636.1) | x¶ | y** |
| Daily-smokers | 8 | 336.7 (273.1) | 211.7 (91.1, 906.4) | 0.614 | |||
| TFW | Never-smokers | 14 | 212.3 (162.6) | 146.4 (67.3, 617.8) | 0.033 | 0.063 | |
| Daily-smokers | 24 | 334.1 (326.5) | 230.5 (60.6, 976.4) | 0.22 | |||
*pg/mL, transformation method.
†Quantiles: 5%, 95%.
‡Linear regression. Significant p values (p<0.05) in bold.
§ng/mL.
¶x (referents, never-smokers) and **y (referents, never-smokers and daily-smokers combined) denote the reference groups for the corresponding statistical analyses.
AA, arachidonic acid; 15-HETE, 15-hydroxyeicosatetraenoic acid; 9-HODE, 9-hydroxyoctadecadienoic acid; PGD2, prostaglandin D2; TFW, tunnel finishing worker.