Table 3

Unadjusted OR and adjusted ORs (AORs) for pulmonary tuberculosis in black miners at autopsy, by calendar period

Variable1975–19891990–20042005–2014
 nOR (95% CI)P values*AOR (95% CI)P values*nOR (95% CI)P values*AOR (95%  CI)P values*nOR (95%  CI)P values*AOR (95%  CI)P values*
Year of autopsy
 1975–1979440ReferenceReference440Reference128Reference440ReferenceReference
 1980–19846011.42 (1.25 to 1.61)<0.0011.31 (1.15 to 1.49)<0.001
 1985–19895804.28 (1.12 to 1.45)<0.0011.09 (0.96 to 1.25)0.182
 1990–19946731.84 (1.62 to 2.08)<0.0011.62 (1.42 to 1.84)<0.001
 1995–199910103.56 (3.16 to 4.00)<0.0012.71 (2.39 to 3.08)<0.001
 2000–200421638.60 (7.71 to 9.59)<0.0015.95 (5.25 to 6.73)<0.001
 2005–2009230312.24 (10.96 to 13.66)<0.0019.79 (8.58 to 11.16)<0.001
 2010–201412078.88 (7.89 to 10.00)<0.0017.78 (6.78 to 8.93)<0.001
Age (years)
 <30367ReferenceReference196ReferenceReference117ReferenceReference
 30–394251.46 (1.26 to 1.68)<0.0011.33 (1.15 to 1.54)<0.00111932.54 (2.24 to 2.88)<0.0011.40 (1.22 to 1.61)<0.0017613.59 (3.09 to 4.16)<0.0011.33 (1.13 to 1.58)0.001
 40–494412.30 (1.99 to 2.65)<0.0011.81 (1.55 to 2.11)<0.00116893.83 (3.39 to 4.34)<0.0011.58 (1.38 to 1.82)<0.00115576.22 (5.40 to 7.16)<0.0011.30 (1.09 to 1.54)0.003
 50–592932.88 (2.46 to 3.39)<0.0012.24 (1.88 to 2.66)<0.0016853.25 (2.84 to 3.73)<0.0011.44 (1.23 to 1.68)<0.0019275.37 (4.63 to 6.23)<0.0011.00 (0.83 to 1.20)0.990
 ≥60953.16 (2.49 to 4.01)<0.0012.47 (1.92 to 3.18)<0.001832.46 (1.96 to 3.10)<0.0011.39 (1.09 to 1.78)<0.0011482.99 (2.43 to 3.68)<0.0010.65 (0.51 to 0.82)0.000
Gold employment duration (years)
 0250ReferenceReference567ReferenceReference826ReferenceReference
 <109360.98 (0.85 to 1.13)0.8061.05 (0.88 to 1.18)0.83211130.70 (0.63 to 0.77)<0.0010.97 (0.87 to 1.09)0.6377180.55 (0.50 to 0.61)<0.0011.13 (1.01 to 1.27)0.030
 10–193401.72 (1.45 to 2.04)<0.0011.10 (0.92 to 1.32)0.30016341.34 (1.21 to 1.47)<0.0011.00 (0.89 to 1.11)0.9349701.84 (1.66 to 2.04)<0.0011.46 (1.29 to 1.64)<0.001
 ≥20952.08 (1.62 to 2.67)<0.0011.05 (0.80 to 1.36)0.7335321.64 (1.45 to 1.86)<0.0010.99 (0.86 to 1.14)0.9219962.41 (2.17 to 2.69)<0.0011.43 (1.26 to 1.63)<0.001
Silicosis
 Absent1311ReferenceReference2960ReferenceReference2473ReferenceReference
 Present3104.15 (3.62 to 4.76)<0.0013.08 (2.65 to 3.57)<0.0018862.32 (2.13 to 2.52)<0.0011.54 (1.4 to 1.69)<0.00110372.89 (2.65 to 3.15)<0.0011.34 (1.20 to 1.49)<0.001
 HIV
 Absent16212477ReferenceReference2258ReferenceReference
 Present13693.28 (3.04 to 3.53)<0.0011.37 (1.25 to 1.49)<0.00112523.06 (2.81 to 3.32)<0.0011.17 (1.07 to 1.28)<0.001
  • χ2 tests for trend were significant (p<0.001) for year, age and gold employment duration groups in each calendar period.

  • *Wald test p values.