Associations between timing of occupation and amyotrophic lateral sclerosis diagnosis in men
| Agriculture, hunting, forestry, fishing | Construction | |||||
| Cases n (%) | Controls n (%) | OR (95% CI) | Cases n (%) | Controls n (%) | OR (95% CI) | |
| Longest job* | 33 (3.06%) | 2800 (2.59%) | 1.14 (0.80 to 1.63) | 69 (6.39%) | 5945 (5.51%) | 1.17 (0.92 to 1.51) |
| Years before diagnosis†‡ | ||||||
| 0 years before | 181 (16.77%) | 16 072 (14.90%) | 1.21 (1.01 to 1.44) | 396 (36.70%) | 37 256 (34.53%) | 1.21 (1.05 to 1.38) |
| 5 years before | 175 (16.22%) | 15 539 (14.40%) | 1.20 (1.01 to 1.44) | 389 (36.05%) | 36 121 (33.48%) | 1.23 (1.07 to 1.41) |
| 10 years before | 170 (15.76%) | 14 826 (13.74%) | 1.21 (1.01 to 1.45) | 375 (34.75%) | 34 454 (31.93%) | 1.25 (1.09 to 1.44) |
| Number of years in the job‡ | ||||||
| None | 901 (83.50%) | 92 127 (85.38%) | Reference | 687 (63.67%) | 71 278 (66.06%) | Reference |
| <1 year | 120 (11.12%) | 9964 (9.23%) | 1.28 (1.04 to 1.58) | 230 (21.32%) | 20 363 (18.87%) | 1.25 (1.06 to 1.47) |
| 1–4 years | 45 (4.17%) | 3676 (3.41%) | 1.36 (0.99 to 1.87) | 93 (8.62%) | 9053 (8.39%) | 1.18 (0.94 to 1.49) |
| ≥5 years | 13 (1.20%) | 2133 (1.98%) | 0.64 (0.36 to 1.14) | 69 (6.39%) | 7206 (6.68%) | 1.13 (0.87 to 1.46) |
| Age at first employment‡ | ||||||
| None | 901 (83.50%) | 92 127 (85.38%) | Reference | 687 (63.67%) | 71 278 (66.06%) | Reference |
| ≤20 years | 51 (4.73%) | 4609 (4.27%) | 1.18 (0.85 to 1.64) | 63 (5.84%) | 5988 (5.55%) | 1.27 (0.95 to 1.68) |
| 21–30 years | 84 (7.78%) | 7453 (6.91%) | 1.22 (0.96 to 1.54) | 218 (20.20%) | 20 402 (18.91%) | 1.22 (1.03 to 1.45) |
| 31–40 years | 25 (2.32%) | 2138 (1.98%) | 1.24 (0.81 to 1.89) | 65 (6.02%) | 6110 (5.66%) | 1.12 (0.85 to 1.48) |
| ≥41 years | 18 (1.67%) | 1573 (1.46%) | 1.23 (0.75 to 2.00) | 46 (4.26%) | 4122 (3.82%) | 1.21 (0.89 to 1.67) |
| Calendar year of first employment‡ | ||||||
| None | 901 (83.50%) | 92 127 (85.38%) | Reference | 687 (63.67%) | 71 278 (66.06%) | Reference |
| ≤1964 | 11 (1.02%) | 1228 (1.14%) | 0.94 (0.51 to 1.72) | 16 (1.48%) | 1673 (1.55%) | 1.07 (0.64 to 1.77) |
| 1965–1974 | 75 (6.95%) | 6454 (5.98%) | 1.23 (0.96 to 1.57) | 188 (17.42%) | 15 479 (14.35%) | 1.35 (1.13 to 1.61) |
| 1975–1984 | 56 (5.19%) | 4544 (4.21%) | 1.32 (0.98 to 1.78) | 98 (9.08%) | 10 205 (9.46%) | 1.05 (0.83 to 1.32) |
| ≥1985 | 33 (3.06%) | 3313 (3.07%) | 1.13 (0.76 to 1.67) | 90 (8.34%) | 9265 (8.59%) | 1.15 (0.90 to 1.49) |
*Models adjusted for socioeconomic status, residential location, marital status and duration.
†Models are separate for each lagged exposure. Percentages presented are for the distribution of subjects with exposure in each case or control group.
‡All models adjusted for socioeconomic status, residential location and marital status.