Significant associations between DNA methylation and gene expression (n=2802)
| CpG | Annotated gene | Ensembl_ID | Gene | B | SE | P adjusted |
| Women | ||||||
| cg16884400 | ATP5G3 | ENSG00000154518 | ATP5G3 | 0.098 | 0.005 | 2.94×10−2 |
| Never-smokers | ||||||
| cg03181524 | RYR1 | ENSG00000196218 | RYR1 | −0.881 | 0.157 | 6.74×10−7 |
| ENSG00000182472 | CAPN12 | −0.877 | 0.194 | 1.86×10−4 | ||
| ENSG00000267892 | CTD-2540F13.2 | −0.916 | 0.234 | 2.76×10−3 | ||
| Subjects with airway obstruction | ||||||
| cg10059942 | HMX2 | ENSG00000154473 | BUB3 | 1.062 | 0.378 | 3.45×10−2 |
| ENSG00000138161 | CUZD1 | 1.474 | 0.536 | 4.18×10−2 | ||
| cg20869844 | RAB19 | ENSG00000146955 | RAB19 | −3.479 | 1.134 | 2.37×10−2 |
| ENSG00000157764 | BRAF | −0.724 | 0.248 | 3.90×10−2 | ||
| cg11465769 | MYT1L | ENSG00000130508 | PXDN | 4.973 | 1.445 | 2.32×10−3 |
| cg19084031* | RP11-1008C21.2 | ENSG00000259225 | RP11-1008C21.1 | −1.711 | 0.177 | 2.34×10−21 |
| ENSG00000166068 | SPRED1 | −0.513 | 0.086 | 1.18×10−8 | ||
| cg04035638 | PSORS1C3;POU5F1 | ENSG00000225851 | HLA-S | 10.888 | 1.621 | 7.57×10−10 |
| ENSG00000204580 | DDR1 | 1.678 | 0.328 | 1.25×10−5 | ||
| ENSG00000137310 | TCF19 | 1.239 | 0.345 | 1.33×10−2 | ||
| ENSG00000228789 | HCG22 | −5.066 | 1.421 | 1.48×10−2 | ||
| ENSG00000234745 | HLA-B | −1.337 | 0.389 | 2.46×10−2 | ||
No data in BIOS-BBMRI were available for cg08855288, cg15793258 and cg27484412. In online supplemental table 5, the results of all CpGs and genes with expression data available within 1 Mb are shown.
*CpG also identified in pesticide exposure×airway obstruction analysis.
B, beta; CpG, DNA methylation site; P adjusted, Bonferroni-corrected P values based on all probesets located within the 1 Mb window.