High pesticide exposure | Sex/current-smoking/airway obstruction | Interaction | ||||||||||||||
CpG | Chr | Bp | Str | Gene | Island | Position | Mean beta (%) | B | SE | P | B | SE | P | B | SE | P |
Pesticide exposure×sex (n=1561) | ||||||||||||||||
cg08855288 | 8 | 63 161 589 | − | NKAIN3 | Island | 5′ UTR | 6.53 | −2.39 | 0.52 | 4.59×10−6 | −0.28 | 0.21 | 0.184 | 2.06 | 0.39 | 1.01×10−7 |
Pesticide exposure×current-smoking (n=1561) | ||||||||||||||||
cg07158503 | 5 | 135 415 693 | − | VTRNA2-1 | N_Shore | TSS1500 | 47.4 | 0.14 | 1.09 | 0.900 | −0.51 | 0.65 | 0.428 | −15.95 | 2.10 | 3.23×10−14 |
cg06478886 | 5 | 135 416 029 | − | VTRNA2-1 | N_Shore | TSS200 | 36.7 | 0.32 | 0.89 | 0.718 | −0.20 | 0.52 | 0.700 | −10.42 | 1.70 | 9.64×10−10 |
cg10994681 | 11 | 31 672 091 | + | ELP4 | Body | Body | 86.2 | −1.31 | 0.36 | 0.0003 | −0.08 | 0.21 | 0.712 | 3.64 | 0.70 | 1.92×10−7 |
cg11608150 | 5 | 135 415 948 | − | VTRNA2-1 | N_Shore | TSS1500 | 30.8 | 0.30 | 1.12 | 0.788 | −0.92 | 0.67 | 0.167 | −11.24 | 2.16 | 2.02×10−7 |
Pesticide exposure×airway obstruction (n=1561) | ||||||||||||||||
cg15793258 | 19 | 4 638 503 | − | TNFAIP8L1 | N_Shore | TSS1500 | 62.6 | −0.59 | 0.76 | 0.440 | −0.57 | 0.30 | 0.058 | −20.19 | 1.69 | 6.19×10−33 |
cg25251562 | 2 | 3 704 773 | − | ALLC | OpenSea | TSS1500 | 83.7 | 0.78 | 0.89 | 0.377 | 0.58 | 0.35 | 0.093 | −12.20 | 1.96 | 4.72×10−10 |
cg12839813 | 16 | 89 114 720 | − | CTD-2555A7.2 | Island | Body | 50.9 | −0.61 | 0.75 | 0.418 | 0.56 | 0.29 | 0.057 | 9.00 | 1.66 | 5.55×10−8 |
cg17623116 | 3 | 26 751 066 | + | LRRC3B | OpenSea | 5′ UTR | 83.6 | 0.57 | 0.52 | 0.007 | 0.15 | 0.08 | 0.064 | −2.43 | 0.46 | 1.61×10−7 |
cg19084031 | 15 | 38 361 362 | − | RP11-1008C21.2 | N_Shelf | 3′ 7 kb | 18.5 | −0.83 | 0.00 | 0.109 | 0.02 | 0.20 | 0.935 | 5.69 | 1.15 | 6.72×10−7 |
B, beta; Bp, base pair; Chr, chromosome; CpG, DNA methylation site; Str, strand, UTR, untranslated region, TSS, transcription start site.