ORs with 95% CI of sinonasal adenocarcinoma, squamous cell carcinoma and a category of other histological subtypes by styrene exposure in the Danish reinforced plastics industry, 1968–2011*
| Exposure metric | Adenocarcinoma (n=9) | Squamous cell carcinoma (n=15) | Other histological subtypes (n=13) | |||
| OR† (95% CI) | OR‡ (95% CI) | OR† (95% CI) | OR‡ (95% CI) | OR† (95% CI) | OR‡ (95% CI) | |
| Cumulative styrene exposure score | ||||||
| <37 mg/m3-years | 1. 00 (reference) | 1.00 (reference) | 1. 00 (reference) | 1.00 (reference) | 1.00 (reference) | 1.00 (reference) |
| ≥37 mg/m3-years | 4.02 (0.44 to 36.6) | 5.11 (0.58 to 45.12) | 1.30 (0.37 to 4.57) | 1.15 (0.34 to 3.89) | 0.88 (0.28 to 2.80) | 0.74 (0.22 to 2.42) |
| Per 100 mg/m3-years | 1.36 (1.09 to 1.68) | 1.08 (0.96 to 1.21) | 0.96 (0.81 to 1.14) | 1.02 (0.83 to 1.25) | 0.80 (0.51 to 1.20 | 0.75 (0.46 to 1.23) |
| Mean styrene exposure intensity | ||||||
| <23 mg/m3 | 1. 00 (reference) | 1.00 (reference) | 1. 00 (reference) | 1.00 (reference) | 1.00 (reference) | 1.00 (reference) |
| ≥23 mg/m3 | 1.85 (0.34 to 10.20) | 2.06 (0.38 to 11.25) | 0.45 (0.14 to 1.47) | 0.43 (0.14 to 1.32) | 0.46 (0.14 to 1.51) | 0.45 (0.13 to 1.53) |
| Per 10 mg/m3 | 1.17 (1.04 to 1.32) | 1.08 (0.98 to 1.18) | 0.99 (0.87 to 1.12) | 0.98 (0.86 to 1.11) | 0.97 (0.87 to 1.09) | 0.95 (0.84 to 1.07) |
| Mean styrene exposure probability | ||||||
| <37% | 1. 00 (reference) | 1.00 (reference) | 1. 00 (reference) | 1.00 (reference) | 1.00 (reference) | 1.00 (reference) |
| ≥37% | 2.08 (0.49 to 8.85) | 1.81 (0.39 to 8.45) | 1.22 (0.41 to 3.62) | 1.40 (0.47 to 4.20) | 1.45 (0.46 to 4.57) | 0.94 (0.29 to 3.04) |
| Per % | 1.02 (0.99 to 1.05) | 1.02 (0.99 to 1.05) | 1.00 (0.98 to 1.02) | 1.00 (0.98 to 1.02) | 1.00 (0.98 to 1.02) | 0.99 (0.97 to 1.01) |
| Duration of employment during styrene production | ||||||
| <5 years | 1. 00 (reference) | 1.00 (reference) | 1. 00 (reference) | 1.00 (reference) | 1.00 (reference) | 1.00 (reference) |
| ≥5 years | 3.72 (0.88 to 15.64) | 2.50 (0.64 to 9.73) | 0.67 (0.18 to 2.46) | 0.96 (0.26 to 3.55) | 0.33 (0.04 to 2.59) | 0.24 (0.03 to 1.95) |
| Per year | 1.07 (0.96 to 1.19) | 1.07 (0.95 to 1.20) | 0.97 (0.86 to 1.10) | 1.04 (0.91 to 1.19) | 0.95 (0.81 to 1.12) | 0.95 (0.80 to 1.14) |
*In accordance with the data confidentiality policy of Statistics Denmark, no less than four cases per cell were reported or should be inferred, and for that reason, only the overall number of cases are presented.
†Cases and controls are matched on age and sex.
‡Cases and controls are matched on age, sex and employment in a reinforced plastics company producing boats or in wood industry (never, ever, unknown).