Table 3

Risk estimates for ASL, HCC and unspecified liver cancer by cumulative exposure from Cox regression models

	ASL, n=63			HCC, n=32			Unspecified liver cancer, n=36
	n	HR	95% CI	n	HR	95% CI	n	HR	95% CI
Cumulative exposure (low cut-points)*
<63 ppm-years				3	Ref		4	Ref
63 to <287 ppm-years				3	1.0	0.2 to 5.1	3	0.8	0.2 to 3.5
287 to <865 ppm-years	4†	Ref		1	0.3	0.03 to 3.0	5	1.2	0.3 to 4.4
865 to <2271 ppm-years	9	6.5	2.0 to 21.0	4	1.1	0.3 to 5.1	6	1.3	0.4 to 4.6
≥2271 ppm-years	50	36.3	13.1 to 100.5	21	5.3	1.6 to 17.7	18	3.6	1.2 to 10.6
Cumulative exposure (high cut-points)‡
<1021 ppm-years	6	Ref		8	Ref		13	Ref
1021 to <3301 ppm-years	12	5.4	2.0 to 14.3	4	1.2	0.4 to 3.8	7	1.3	0.5 to 3.2
3301 to <5686 ppm-years	11	18.3	6.8 to 49.4	7	7.2	2.6 to 20.0	9	6.0	2.5 to 13.9
5686 to <10 551 ppm-years	18	38.1	15.1 to 96.0	6	7.3	2.5 to 21.1	4	3.2	1.0 to 9.7
≥10 551 ppm-years	16	73.6	28.8 to 188.4	7	18.8	6.8 to 51.9	3	5.2	1.5 to 18.2

*Low cut-points are based on quintiles of cumulative exposure for the entire cohort.
†Due to zero cases in the referent group, one case in the second quintile and three in the third quintile, the first three quintiles have been collapsed to form a single referent category.
‡High cut-points are based on quintiles of cumulative exposure for all liver cancers in the entire cohort.
ASL, angiosarcoma of the liver; HCC, hepatocellular carcinoma; Ref, referent.