Association between an estimated parental ≥20 pg/g TCDD serum concentration at time of birth and the probability of a parent-reported health problem in the offspring
| 355 births after start of employment | ||||||
|---|---|---|---|---|---|---|
| TCDD<20 pg/g (n=218) | TCDD≥20 pg/g (n=137) | OR* (95% CI) | OR for ln-TCDD continuous (95% CI) | |||
| Any health problem reported | 33 | 15% | 24 | 18% | 1.33 (0.72 to 2.45) | 1.10 (0.91 to 1.32) |
| Congenital malformation | 13 | 6% | 5 | 4% | 0.54 (0.16 to 1.85) | 0.89 (0.68 to 1.16) |
| Thyroid/gland problem† | 0 | 0% | 3 | 2% | – | 1.85 (1.37 to 2.48) |
*OR adjusted for: age of parent at year of birth, sex of exposed parent, sex of child.
†Thyroid/gland problem refers to the parent reporting that their offspring had ‘gland problems’, ‘thyroid problems’ or ‘thyroid surgery’. For none of the offspring with reported thyroid/gland problem, the parent reported they had a thyroid problem themselves. Of the three children reported to have thyroid problems, two were from an exposed father and one from an exposed mother. The OR could not be adjusted for age of exposed parent at year of birth.
TCDD, 2,3,7,8-tetrachlorodibenzo-p-dioxin.