Crude and adjusted ORs and 95% CIs for congenital anomalies by exposure to TTHM levels (µg/l) during the first trimester of pregnancy
| Total trihalomethane exposure (µg/l) | Cases n (%) | Controls n (%) | Crude OR | 95% CI | Adjusted OR | 95% CI |
|---|---|---|---|---|---|---|
| Heart anomalies | ||||||
| Low (1.3 µg/l) | 20 (35.1) | 1325 (45.6) | 1 | 1 | ||
| High (21.9 µg/l) | 37 (64.9) | 1578 (54.4) | 1.55 | 0.89 to 2.69 | 1.54* | 0.89 to 2.68 |
| Musculoskeletal anomalies | ||||||
| Low (1.3 µg/l) | 19 (51.4) | 1325 (45.6) | 1 | 1 | ||
| High (21.9 µg/l) | 18 (48.6) | 1578 (54.4) | 0.80 | 0.42 to 1.52 | 0.74† | 0.39 to 1.42 |
| Urogenital anomalies | ||||||
| Low (1.3 µg/l) | 5 (21.7) | 1325 (45.6) | 1 | 1 | ||
| High (21.9 µg/l) | 18 (78.3) | 1578 (54.4) | 3.02 | 1.12 to 8.16 | 3.01‡ | 1.11 to 8.16 |
High–Petrasiunai; Low–Other water supply zones.
*Adjusted for: age, body mass index, chronic disease, alcohol consumption and fetus number.
†Adjusted for: body mass index, fetus number, previous premature birth and infant sex.
‡Adjusted for: age, body mass index, chronic disease, previous premature birth and infant sex.