Table 2

Association between ESRD risk and acute and cumulative pesticide exposure, adjusted for age and state, among male pesticide applicators, Agricultural Health Study (1993–1997)

VariableNon-cases
(N=55 260)
N (%)
ESRD cases
(N=320)
N (%)
HR (95% CI)p for trend
Number of times ever visited a medical doctor due to pesticide use
 None49 764 (93.4)272 (91.3)
 Once2635 (4.9)15 (5)1.07 (0.64 to 1.8)
 More than once884 (1.7)11 (3.7)2.13 (1.17 to 3.89)
0.0384
Ever hospitalised due to pesticide use
 No51 619 (98.9)275 (96.2)
 Yes572 (1.1)11 (3.8)3.05 (1.67 to 5.58)
Ever experienced unusually high personal pesticide exposure*
 No20 112 (84.8)115 (87.1)
 Yes3596 (15.2)17 (12.9)1.08 (0.65 to 1.81)
Ever diagnosed with pesticide poisoning*
 No23 506 (98.0)126 (96.2)
 Yes484 (2.0)5 (3.8)1.59 (0.65 to 3.89)
Cumulative lifetime-days personally mixed or applied pesticides
 0–6413 850 (27.1)78 (28.0)
 65–22515 637 (30.6)69 (24.7)0.89 (0.64 to 1.24)
 226–4577307 (14.3)41 (14.7)0.95 (0.65 to 1.39)
 >45714 314 (28.0)91 (32.6)1.07 (0.79 to 1.44)
0.4667
  • *Question asked only on the take-home questionnaire: N (non-cases)=24 429 and N (cases)=136.

  • ESRD, end-stage renal disease.