OPs | Malathion | Diazinon | Chlorpyrifos | Terbufos | ||||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Ntotal† | N‡ | RR | 95% CI | N | RR | 95% CI | N | RR | 95% CI | N | RR | 95% CI | N | RR | 95% CI | |
All sites§ | 1953 | 528 | 1.08 | 0.94 to 1.23 | 411 | 1.04 | 0.91 to 1.18 | 209 | 1.08 | 0.93 to 1.25 | 82 | 1.05 | 0.79 to 1.38 | 64 | 1.17 | 0.83 to 1.66 |
Breast§ | 740 | 206 | 1.21 | 0.98 to 1.49 | 156 | 1.10 | 0.89 to 1.35 | 88 | 1.24 | 0.99 to 1.56 | 36 | 1.45 | 0.97 to 2.18 | 27 | 1.61 | 0.96 to 2.72 |
ER+PR+ | 431 | 122 | 1.22 | 0.93 to 1.61 | 95 | 1.11 | 0.85 to 1.45 | 46 | 1.10 | 0.81 to 1.51 | 19 | 1.20 | 0.68 to 2.11 | 15 | 1.39 | 0.68 to 2.81 |
ER−PR− | 115 | 35 | 1.19 | 0.71 to 1.99 | 25 | 1.04 | 0.62 to 1.74 | 16 | 1.48 | 0.86 to 2.55 | ||||||
Colon | 143 | 35 | 0.87 | 0.52 to 1.44 | 29 | 0.95 | 0.58 to 1.57 | 15 | 1.06 | 0.60 to 1.87 | ||||||
Leukaemia | 48 | 15 | 0.92 | 0.41 to 2.11 | 11 | 0.79 | 0.34 to 1.85 | |||||||||
Lung | 124 | 29 | 0.81 | 0.46 to 1.42 | 26 | 1.11 | 0.63 to 1.93 | 13 | 1.06 | 0.56 to 2.00 | ||||||
Melanoma | 72 | 21 | 1.02 | 0.53 to 1.97 | 15 | 0.82 | 0.42 to 1.59 | |||||||||
NHL | 152 | 46 | 1.10 | 0.69 to 1.74 | 27 | 0.60 | 0.37 to 0.98 | 17 | 1.14 | 0.66 to 1.96 | ||||||
FL | 30 | 11 | 1.02 | 0.38 to 2.76 | ||||||||||||
MM | 27 | 11 | 3.00 | 1.08 to 8.34 | ||||||||||||
Ovary§ | 61 | 18 | 1.55 | 0.75 to 3.18 | 15 | 1.28 | 0.64 to 2.56 | 10 | 1.88 | 0.93 to 3.78 | ||||||
Pancreas | 35 | 14 | 1.62 | 0.65 to 4.08 | 12 | 1.46 | 0.62 to 3.44 | |||||||||
Rectum | 44 | 11 | 0.96 | 0.39 to 2.41 | ||||||||||||
Thyroid | 73 | 21 | 1.41 | 0.74 to 2.69 | 19 | 2.22 | 1.18 to 4.17 | |||||||||
Uterus§ | 170 | 47 | 1.03 | 0.66 to 1.59 | 37 | 1.09 | 0.71 to 1.67 | 15 | 0.81 | 0.47 to 1.41 |
Dichlorvos | Phorate | Fonofos | Coumaphos | Parathion | ||||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Ntotal | N | RR | 95% CI | N | RR | 95% CI | N | RR | 95% CI | N | RR | 95% CI | N | RR | 95% CI | |
All sites§ | 1953 | 53 | 0.95 | 0.72 to 1.26 | 42 | 0.86 | 0.60 to 1.22 | 42 | 0.90 | 0.61 to 1.33 | 27 | 1.00 | 0.68 to 1.47 | 26 | 1.20 | 0.81 to 1.79 |
Breast§ | 740 | 19 | 1.05 | 0.66 to 1.67 | 16 | 0.94 | 0.53 to 1.65 | 12 | 0.66 | 0.33 to 1.31 | 15 | 1.64 | 0.98 to 2.74 | 13 | 1.72 | 0.99 to 2.99 |
ER+PR+ | 431 | 14 | 1.21 | 0.70 to 2.08 | 10 | 0.99 | 0.48 to 2.03 |
*Adjusted for age, race, state, pack-years smoked, family history of cancer, alcohol consumption, BMI, education, home and garden pesticide application and correlated/associated pesticide use.
†Total cases.
‡Exposed cases.
§Additionally adjusted for menopause status at enrolment, number of live births, and oral contraceptive use.
AHS, Agricultural Health Study; BMI, body mass index; ER, estrogen receptor; FL, follicular Lymphoma; MM, multiple Myeloma; NHL, non-Hodgkin Lymphoma; OP, organophosphates; PR, progesterone receptor; RR, relative risks.