Multivariate analysis of subtype of myeloid and lymphoid leukaemia cases by job exposure matrix
| Exposure | Acute myeloid leukaemia n=113 | Chronic myeloid leukaemia n=46 | Chronic lymphoid leukaemia n=216 | |||
|---|---|---|---|---|---|---|
| Multivariate HR (95% CI) | p Value* | Multivariate HR (95% CI) | p Value* | Multivariate HR (95% CI) | p Value* | |
| Pesticides | ||||||
| No | 1.00 | 0.79 | 1.00 | 0.34 | 1.00 | 0.86 |
| Low | 0.85 (0.41 to 1.79) | 2.01 (0.81 to 4.99) | 1.05 (0.65 to 1.69) | |||
| High | 1.19 (0.60 to 2.37) | 1.33 (0.50 to 3.56) | 1.03 (0.63 to 1.69) | |||
| Herbicides | ||||||
| No | 1.00 | 0.91 | 1.00 | 0.35 | 1.00 | 0.89 |
| Low | – | – | – | |||
| High | 0.97 (0.54 to 1.73) | 1.45 (0.66 to 3.20) | 1.02 (0.69 to 1.53) | |||
| Insecticides | ||||||
| No | 1.00 | 0.79 | 1.00 | 0.34 | 1.00 | 0.86 |
| Low | 0.85 (0.40 to 1.79) | 2.01 (0.81 to 4.99) | 1.05 (0.65 to 1.69) | |||
| High | 1.19 (0.60 to 2.37) | 1.33 (0.50 to 3.56) | 1.03 (0.63 to 1.69) | |||
| Aromatic solvents | ||||||
| No | 1.00 | 0.17 | 1.00 | 0.41 | 1.00 | 0.52 |
| Low | 1.15 (0.73 to 1.80) | 0.67 (0.33 to 1.35) | 0.97 (0.72 to 1.32) | |||
| High | 1.83 (0.86 to 3.88) | 0.97 (0.23 to 4.13) | 0.71 (0.33 to 1.53) | |||
| Benzene | ||||||
| No | 1.00 | 0.28 | 1.00 | 0.30 | 1.00 | 0.37 |
| Low | 1.06 (0.63 to 1.81) | 1.00 (0.45 to 2.22) | 1.11 (0.78 to 1.58) | |||
| High | 1.52 (0.78 to 2.98) | 1.97 (0.75 to 5.19) | 0.56 (0.27 to 1.14) | |||
| Chlorinated solvents | ||||||
| No | 1.00 | 0.58 | 1.00 | 0.83 | 1.00 | 0.77 |
| Low | 1.20 (0.79 to 1.80) | 0.73 (0.38 to 1.41) | 0.97 (0.73 to 1.28) | |||
| High | 0.79 (0.19 to 3.30) | 1.74 (0.50 to 6.10) | 0.91 (0.37 to 2.26) | |||
| Trichloroethylene | ||||||
| No | 1.00 | 0.77 | 1.00 | 0.80 | 1.00 | 0.33 |
| Low | 1.00 (0.66 to 1.51) | 0.98 (0.51 to 1.87) | 0.93 (0.69 to 1.24) | |||
| High | 0.73 (0.22 to 2.38) | 0.77 (0.18 to 3.42) | 0.64 (0.28 to 1.47) | |||
| Formaldehyde | ||||||
| No | 1.00 | 0.74 | 1.00 | 0.70 | 1.00 | 0.36 |
| Low | 1.01 (0.65 to 1.57) | 0.92 (0.46 to 1.84) | 1.12 (0.83 to 1.52) | |||
| High | – | – | 1.45 (0.46 to 4.56) | |||
| Metals | ||||||
| No | 1.00 | 0.98 | 1.00 | 0.97 | 1.00 | 0.34 |
| Low | 0.97 (0.59 to 1.60) | 0.82 (0.36 to 1.84) | 0.89 (0.63 to 1.26) | |||
| High | 1.06 (0.45 to 2.54) | 1.23 (0.41 to 3.72) | 0.75 (0.38 to 1.50) | |||
| Contact with animals or animal products | ||||||
| No | 1.00 | 0.45 | 1.00 | 0.28 | 1.00 | 0.94 |
| Low | 0.46 (0.11 to 1.86) | 2.43 (0.85 to 7.01) | 1.05 (0.54 to 2.07) | |||
| High | 0.85 (0.48 to 1.51) | 1.37 (0.62 to 3.02) | 1.01 (0.69 to 1.49) | |||
| Ionising radiation | ||||||
| No | 1.00 | 0.51 | 1.00 | 0.54 | 1.00 | 0.14 |
| Low | 0.83 (0.40 to 1.72) | 0.73 (0.22 to 2.39) | 1.45 (0.96 to 2.17) | |||
| High | – | – | – | |||
Multivariate analyses were adjusted for sex, smoking status, alcohol intake, age at recruitment and country.
*Tests of linear trend across categories were conducted by fitting a model treating the different tertile categories as a single ordinal variable.